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Details on Person MCIDAS binds to TFDP1 and E2F4 or E2F5 to regulate transcrip...
| Class:Id | Summation:9960612 |
|---|---|
| _displayName | MCIDAS binds to TFDP1 and E2F4 or E2F5 to regulate transcrip... |
| _timestamp | 2026-05-08 19:03:13 |
| created | [InstanceEdit:9960610] Rothfels, Karen, 2025-07-16 |
| modified | [InstanceEdit:9960870] Rothfels, Karen, 2025-07-17 [InstanceEdit:9962308] Rothfels, Karen, 2025-08-03 [InstanceEdit:9988570] Rothfels, Karen, 2026-05-08 [InstanceEdit:9988640] Rothfels, Karen, 2026-05-08 |
| text | MCIDAS binds to TFDP1 and E2F4 or E2F5 to regulate transcription of genes important for multiciliogenesis as assessed in studies in Xenopus (Tan et al, 2013; Ma et al, 2014). MCIDAS does not contain a DNA-binding domain, so depends on interaction with E2F4 or E2F5 and TFDP1 for recruitment to target promoters (Ma et al, 2014; Mori et al, 2017; reviewed in Nemajerova et al, 2018; Cumplido-Lasso et al, 2023). Ternary complex formation depends on the C-terminal TIRT domain of MCIDAS and the dimerization domains of E2F4, E2F5 and TFDP1 (Ma et al, 2014). Note that although this reaction shows MCIDAS binding to TFDP1 and E2F transcription factors as a dimer, this has not been experimentally demonstrated. Although numerous studies have demonstrated a dependence on MCIDAS for expression of genes important for multiciliogenesis such as FOXJ1, TP73 and RFX proteins (Boon et al, 2014; Stubbs et al, 2012; Choksi et al, 2014; Jackson and Attardi, 2016; Lu et al, 2025), other studies have suggested that the MCIDAS-related protein GMNC is responsible for establishing multiciliated cell precursors (MCCs), while MCIDAS is responsible for driving basal body production (Lu et al, 2019). In this latter study, disruption of MCIDAS in mice did not abrogate expression of FOXJ1, TP73 and other key multiciliogenesis genes, but rather disrupted expression of genes involved in basal body amplification, and consistent with this showed that MCIDAS-mutant mouse cultures are associated with a single basal body and single cilium (Lu et al, 2019; reviewed in Cumplido-Lasso et al, 2023). |
| (summation) | [Reaction:9960756] MCIDAS dimer binds E2F4, E2F5 and TFDP1 [Homo sapiens] |
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No pathways have been reviewed or authored by MCIDAS binds to TFDP1 and E2F4 or E2F5 to regulate transcrip... (9960612)
