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Details on Person Formation of RV-A transcription complex (RV-A TC)

Class:Id	Reaction:9960589
_displayName	Formation of RV-A transcription complex (RV-A TC)
_doRelease	FALSE
_timestamp	2026-01-21 18:44:19
authored	[InstanceEdit:9979788] Orlic-Milacic, Marija, 2026-01-21
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9960588] Orlic-Milacic, Marija, 2025-07-16
disease	[Disease:3134794] viral infectious disease
input	[EntityWithAccessionedSequence:9960978] VP1 [cytosol] [Rotavirus A] [Complex:9821169] VP2 decamer [cytosol] [Rotavirus A] [Complex:9821134] VP3 tetramer [cytosol] [Rotavirus A] [SimpleEntity:29926] Mg2+ [cytosol] [SimpleEntity:29926] Mg2+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9973838] Mutational analysis of residues involved in nucleotide and divalent cation stabilization in the rotavirus RNA-dependent RNA polymerase catalytic pocket [LiteratureReference:9974078] Template recognition and formation of initiation complexes by the replicase of a segmented double-stranded RNA virus
modified	[InstanceEdit:9960998] Orlic-Milacic, Marija, 2025-07-18 [InstanceEdit:9966052] Orlic-Milacic, Marija, 2025-09-09 [InstanceEdit:9973841] Orlic-Milacic, Marija, 2025-11-17 [InstanceEdit:9974082] Orlic-Milacic, Marija, 2025-11-19 [InstanceEdit:9979789] Orlic-Milacic, Marija, 2026-01-21 [InstanceEdit:9979800] Orlic-Milacic, Marija, 2026-01-21
name	Formation of RV-A transcription complex (RV-A TC)
output	[Complex:9960975] RV-A RTC [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9965293] Translation of RV-A VP1 [Homo sapiens] [Reaction:9966113] NSP3 binds eIF4G [Homo sapiens] [BlackBoxEvent:9960591] Release of RV-A capped mRNAs from DLPs to cytosol [Homo sapiens] [BlackBoxEvent:9821148] VP2 forms a decamer [Homo sapiens] [BlackBoxEvent:9965288] Translation of RV-A VP2 [Homo sapiens] [Reaction:9821170] VP3 forms a tetramer [Homo sapiens] [BlackBoxEvent:9965295] Translation of RV-A VP3 [Homo sapiens]
relatedSpecies	[Species:9615053] Rotavirus A
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9960600] R-HSA-9960589.1
structureModified	[InstanceEdit:9960998] Orlic-Milacic, Marija, 2025-07-18 [InstanceEdit:9973841] Orlic-Milacic, Marija, 2025-11-17
summation	[Summation:9960596] Rotavirus A (RV-A) replication and transcription complex (RT...
(hasEvent)	[Pathway:9819331] Genome Replication, Assembly and Release of Rotavirus A (RV-A) triple-layer particles (TLPs) [Homo sapiens]
(precedingEvent)	[Reaction:9960595] RV-A RTCs bind RV-A genomic dsRNA segments [Reaction:9973110] Formation of RV-A single-layered particles [Homo sapiens] [Reaction:9973136] Capped +ssRNA binds RV-A replication and transcription complex [Homo sapiens]
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No pathways have been reviewed or authored by Formation of RV-A transcription complex (RV-A TC) (9960589)