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Details on Person CASP4 cleaves IL1B at D116

Class:IdBlackBoxEvent:9960526
_displayNameCASP4 cleaves IL1B at D116
_doReleaseTRUE
_timestamp2025-08-18 13:53:13
authored[InstanceEdit:9947804] Shamovsky, Veronica, 2025-05-14
catalystActivity[CatalystActivity:9948006] cysteine-type endopeptidase activity of activated CASP4 [cytosol]
catalystActivityReference[CatalystActivityReference:9960524] cysteine-type endopeptidase activity of activated CASP4 [cytosol] Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme
compartment[Compartment:70101] cytosol
created[InstanceEdit:9960523] Shamovsky, Veronica, 2025-07-14
edited[InstanceEdit:9963520] Shamovsky, Veronica, 2025-08-14
input[EntityWithAccessionedSequence:448689] IL1B(1-269) [cytosol] [Homo sapiens]
internalReviewed[InstanceEdit:9960500] Matthews, Lisa, 2025-07-09
isChimericFALSE
literatureReference[LiteratureReference:9947979] Structural insights into cytokine cleavage by inflammatory caspase-4
[LiteratureReference:9947803] Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme
modified[InstanceEdit:9960533] Shamovsky, Veronica, 2025-07-14
[InstanceEdit:9963536] Shamovsky, Veronica, 2025-08-14
[InstanceEdit:9963953] Shamovsky, Veronica, 2025-08-18
nameCASP4 cleaves IL1B at D116
output[EntityWithAccessionedSequence:449046] IL1B(117-269) [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:449030] IL1B(1-116) [cytosol] [Homo sapiens]
precedingEvent
releaseDate2025-09-18
reviewed[InstanceEdit:9963135] Shi, Xuyan, 2025-08-12
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9960527] R-HSA-9960526.1
summation[Summation:9960521] While caspase-1 (CASP1) is the primary enzyme responsible fo...
(hasEvent)[Pathway:9960519] CASP4-mediated substrate cleavage [Homo sapiens]
(precedingEvent)[BlackBoxEvent:449058] Interleukin-1 family are secreted [Homo sapiens]
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No pathways have been reviewed or authored by CASP4 cleaves IL1B at D116 (9960526)