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Details on Person SIRT1 deacetylates Ac-K16-Histone H4 and Ac-K9,K14-Histone H3 at the PER2 locus

Class:Id	Reaction:9960053
_displayName	SIRT1 deacetylates Ac-K16-Histone H4 and Ac-K9,K14-Histone H3 at the PER2 locus
_timestamp	2026-03-23 17:43:47
authored	[InstanceEdit:9960070] May, Bruce, 2025-06-27
catalystActivity	[CatalystActivity:9961881] NAD-dependent protein lysine deacetylase activity of SIRT1:p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome with H3K9acK14ac and H4K16ac:PER2 gene [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9960072] May, Bruce, 2025-07-06
crossReference	[DatabaseIdentifier:9854455] RHEA:43636
edited	[InstanceEdit:9960070] May, Bruce, 2025-06-27
inferredFrom	[Reaction:9960067] Sirt1 deacetylates Ac-K16-histone H4 and Ac-K9,K14-histone H3 at the Dbp or Per2 locus [Mus musculus]
input	[SimpleEntity:113518] H2O [nucleoplasm] [SimpleEntity:113518] H2O [nucleoplasm] [SimpleEntity:113518] H2O [nucleoplasm] [SimpleEntity:113518] H2O [nucleoplasm] [SimpleEntity:113518] H2O [nucleoplasm] [SimpleEntity:113518] H2O [nucleoplasm] [SimpleEntity:427523] NAD+ [nucleoplasm] [SimpleEntity:427523] NAD+ [nucleoplasm] [SimpleEntity:427523] NAD+ [nucleoplasm] [SimpleEntity:427523] NAD+ [nucleoplasm] [SimpleEntity:427523] NAD+ [nucleoplasm] [SimpleEntity:427523] NAD+ [nucleoplasm] [Complex:9860206] SIRT1:p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome with H3K9acK14ac and H4K16ac:PER2 gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9985656] Gillespie, Marc E, 2026-03-23
isChimeric	FALSE
literatureReference	[LiteratureReference:5211373] Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin
modified	[InstanceEdit:9960863] May, Bruce, 2025-07-17 [InstanceEdit:9961274] May, Bruce, 2025-07-22 [InstanceEdit:9961849] May, Bruce, 2025-07-27 [InstanceEdit:9961896] May, Bruce, 2025-07-28 [InstanceEdit:9983816] May, Bruce, 2026-02-27 [InstanceEdit:9985658] May, Bruce, 2026-03-23
name	SIRT1 deacetylates Ac-K16-Histone H4 and Ac-K9,K14-Histone H3 at the PER2 locus
output	[Complex:9960092] SIRT1:p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome:PER2 gene [nucleoplasm] [Homo sapiens] [SimpleEntity:427498] 2'-O-acetyl-ADP-ribose [nucleoplasm] [SimpleEntity:427498] 2'-O-acetyl-ADP-ribose [nucleoplasm] [SimpleEntity:427498] 2'-O-acetyl-ADP-ribose [nucleoplasm] [SimpleEntity:427498] 2'-O-acetyl-ADP-ribose [nucleoplasm] [SimpleEntity:427498] 2'-O-acetyl-ADP-ribose [nucleoplasm] [SimpleEntity:427498] 2'-O-acetyl-ADP-ribose [nucleoplasm] [SimpleEntity:427497] NAM [nucleoplasm] [SimpleEntity:427497] NAM [nucleoplasm] [SimpleEntity:427497] NAM [nucleoplasm] [SimpleEntity:427497] NAM [nucleoplasm] [SimpleEntity:427497] NAM [nucleoplasm] [SimpleEntity:427497] NAM [nucleoplasm]
precedingEvent	[BlackBoxEvent:9958954] p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK positively regulates expression of SIRT1 [Homo sapiens] [Reaction:9961809] CLOCK acetylates BMAL1 in p-S90-BMAL1:p-T451,T461:S440,S441,S446-CLOCK:Nucleosome:SIRT1 gene [Homo sapiens] [Reaction:9961808] CLOCK acetylates Histone H3 and Histone H4 in p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome:SIRT1 gene [Homo sapiens] [BlackBoxEvent:9961806] NAD+ translocates from the cytosol to the nucleoplasm [Homo sapiens] [Reaction:197271] NADSYN1 hexamer amidates NAAD to NAD+ [Homo sapiens] [Reaction:8939959] NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ [Homo sapiens] [Reaction:9961813] NMNAT1 transfers an adenylyl group from ATP to nicotinamide mononucleotide (NMN), yielding NAD+ and pyrophosphate (PPi) [Homo sapiens] [Reaction:9961800] NAMPT transfers 5-phosphoribose from 5-phosphoribose-1-pyrophosphate (PRPP) to nicotinamide (NAM), yielding nicotinamide mononucleotide (NMN) and pyrophosphate [Homo sapiens]
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9960108] R-HSA-9960053.1
structureModified	[InstanceEdit:9961274] May, Bruce, 2025-07-22 [InstanceEdit:9961896] May, Bruce, 2025-07-28
summation	[Summation:9961259] In vitro, SIRT1 preferentially deacetylates lysine-16 of his...
(hasEvent)	[Pathway:9958957] NAD+ and Sirtuins regulate the circadian clock [Homo sapiens]
(precedingEvent)	[Reaction:9961800] NAMPT transfers 5-phosphoribose from 5-phosphoribose-1-pyrophosphate (PRPP) to nicotinamide (NAM), yielding nicotinamide mononucleotide (NMN) and pyrophosphate [Homo sapiens]
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