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Query author contributions in Reactome

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Details on Person OTC gene expression

Class:IdBlackBoxEvent:9959881
_displayNameOTC gene expression
_doReleaseTRUE
_timestamp2026-05-07 22:30:44
authored[InstanceEdit:9959888] Rothfels, Karen, 2025-07-02
compartment[Compartment:459] cytoplasm
[Compartment:7660] nucleoplasm
created[InstanceEdit:9959882] Rothfels, Karen, 2025-07-02
edited[InstanceEdit:9959888] Rothfels, Karen, 2025-07-02
goBiologicalProcess[GO_BiologicalProcess:258336] gene expression
input[EntityWithAccessionedSequence:9959831] OTC gene [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9960015] Orlic-Milacic, Marija, 2025-07-04
[InstanceEdit:9988070] D'Eustachio, Peter, 2026-05-01
[InstanceEdit:9988524] D'Eustachio, Peter, 2026-05-07
isChimericFALSE
literatureReference[LiteratureReference:9959848] p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis
[LiteratureReference:350552] Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase
[LiteratureReference:9955559] A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane
[LiteratureReference:9959828] Polyamines in cancer: integrating organismal metabolism and antitumour immunity
modified[InstanceEdit:9960130] Rothfels, Karen, 2025-07-07
[InstanceEdit:9970980] Rothfels, Karen, 2025-11-03
[InstanceEdit:9988059] D'Eustachio, Peter, 2026-05-01
[InstanceEdit:9988069] D'Eustachio, Peter, 2026-05-01
[InstanceEdit:9988525] D'Eustachio, Peter, 2026-05-07
[InstanceEdit:9988528] D'Eustachio, Peter, 2026-05-07
nameOTC gene expression
output[EntityWithAccessionedSequence:9956408] OTC precursor [cytosol] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
regulatedBy[NegativeGeneExpressionRegulation:9959883] Negative gene expression regulation by 'TP53 tetramer:OTC gene [nucleoplasm]'
regulationReference[RegulationReference:9959879] Negative gene expression regulation by 'TP53 tetramer:OTC gene [nucleoplasm]' p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis
releaseDate2025-12-08
reviewed[InstanceEdit:9988529] Hill, David P, 2026-05-07
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9959884] R-HSA-9959881.1
summation[Summation:9959880] OTC gene expression is repressed by the binding of TP53 tetr...
(hasEvent)[Pathway:9988426] Negative transcriptional regulation of urea cycle enzymes [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9956502] OTC precursor is targeted to the mitochondrial matrix and processed [Homo sapiens]
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No pathways have been reviewed or authored by OTC gene expression (9959881)
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