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Details on Person TP53 binds ARG1 gene

Class:IdReaction:9959857
_displayNameTP53 binds ARG1 gene
_doReleaseTRUE
_timestamp2026-05-07 22:30:51
authored[InstanceEdit:9959888] Rothfels, Karen, 2025-07-02
catalystActivity[CatalystActivity:9988056] DNA-binding transcription repressor activity of TP53 Tetramer [nucleoplasm]
catalystActivityReference[CatalystActivityReference:9988060] DNA-binding transcription repressor activity of TP53 Tetramer [nucleoplasm] p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9959853] Rothfels, Karen, 2025-07-02
edited[InstanceEdit:9959888] Rothfels, Karen, 2025-07-02
input[Complex:3209194] TP53 Tetramer [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:9959833] ARG1 gene [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9960015] Orlic-Milacic, Marija, 2025-07-04
[InstanceEdit:9988070] D'Eustachio, Peter, 2026-05-01
[InstanceEdit:9988524] D'Eustachio, Peter, 2026-05-07
isChimericFALSE
literatureReference[LiteratureReference:9959848] p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis
[LiteratureReference:9959828] Polyamines in cancer: integrating organismal metabolism and antitumour immunity
modified[InstanceEdit:9960130] Rothfels, Karen, 2025-07-07
[InstanceEdit:9970980] Rothfels, Karen, 2025-11-03
[InstanceEdit:9988059] D'Eustachio, Peter, 2026-05-01
[InstanceEdit:9988069] D'Eustachio, Peter, 2026-05-01
[InstanceEdit:9988525] D'Eustachio, Peter, 2026-05-07
[InstanceEdit:9988528] D'Eustachio, Peter, 2026-05-07
nameTP53 binds ARG1 gene
output[Complex:9959839] TP53 tetramer:ARG1 gene [nucleoplasm] [Homo sapiens]
previousReviewStatus[ReviewStatus:9821383] three stars
releaseDate2025-12-08
reviewed[InstanceEdit:9988529] Hill, David P, 2026-05-07
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9959858] R-HSA-9959857.1
structureModified[InstanceEdit:9988059] D'Eustachio, Peter, 2026-05-01
summation[Summation:9959849] TP53 binds to the ARG1 genomic region to repress transcripti...
(hasEvent)[Pathway:9988426] Negative transcriptional regulation of urea cycle enzymes [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9959871] ARG1 gene expression [Homo sapiens]
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No pathways have been reviewed or authored by TP53 binds ARG1 gene (9959857)