Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Inflammatory caspases, particularly caspase-1, -4, -5 mediat...

Class:IdSummation:9959667
_displayNameInflammatory caspases, particularly caspase-1, -4, -5 mediat...
_timestamp2025-08-14 10:15:06
created[InstanceEdit:9959666] Shamovsky, Veronica, 2025-07-01
literatureReference[LiteratureReference:9956664] The E. coli effector protein NleF is a caspase inhibitor
[LiteratureReference:9956675] The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection
[LiteratureReference:9652641] Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases
[LiteratureReference:9956594] Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis
[LiteratureReference:9956643] Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11
modified[InstanceEdit:9963551] Shamovsky, Veronica, 2025-08-14
textInflammatory caspases, particularly caspase-1, -4, -5 mediate pyroptosis, a form of cell death that releases inflammatory cytokines. Dysregulation of inflammatory caspase activation can contribute to dysfunctional pyroptosis and host inflammatory responces (Man SM et al., 2017). Microbes and their products can influence inflammatory caspase activity and contribute to inflammatory diseases (Kobayashi T et al., 2013; Blasche S et al., 2013; Li Z et al., 2021; Hou Y et al., 2023).
(summation)[Pathway:9959668] Diseases associated with inflammatory caspases [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Inflammatory caspases, particularly caspase-1, -4, -5 mediat... (9959667)
Follow Reactome