Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person ARG1 I11T [cytosol]

Class:IdEntityWithAccessionedSequence:9959613
_displayNameARG1 I11T [cytosol]
_timestamp2025-06-30 19:46:05
compartment[Compartment:70101] cytosol
created[InstanceEdit:9959612] Rothfels, Karen, 2025-06-30
crossReference[DatabaseIdentifier:9959581] ClinGen:CA339975
disease[Disease:9956469] hyperargininemia
endCoordinate322
hasModifiedResidue[ReplacedResidue:9959537] L-isoleucine 11 replaced with L-threonine
literatureReference[LiteratureReference:9959590] Analysis of novel ARG1 mutations causing hyperargininemia and correlation with arginase I activity in erythrocytes
nameARG1 I11T
arginase 1
liver-type arginase
Arginase 1
referenceEntity[ReferenceGeneProduct:50257] UniProt:P05089 ARG1 [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9959614] R-HSA-9959613.1
startCoordinate1
(hasMember)[CandidateSet:9959636] ARG1 variants that disrupt enzyme stability and folding [cytosol] [Homo sapiens]
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No pathways have been reviewed or authored by ARG1 I11T [cytosol] (9959613)