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Details on Person UniProt:P26043 Rdx
| Class:Id | ReferenceGeneProduct:99595 |
|---|---|
| _chainChangeLog | chain:1-583 added on Sat February 7 2015;chain:1-583 removed on Fri May 8 2015;initiator methionine:1 added on Fri May 8 2015;chain:2-583 added on Fri May 8 2015;initiator methionine:1 removed on Fri August 12 2016;chain:2-583 removed on Fri August 12 2016;chain:1-583 added on Fri August 12 2016 |
| _displayName | UniProt:P26043 Rdx |
| _timestamp | 2024-08-09 18:55:45 |
| chain | chain:1-583 |
| checksum | 25752653017F0879 |
| comment | FUNCTION Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.ACTIVITY REGULATION A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding.SUBUNIT Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (PubMed:12522145). Binds NHERF1 (By similarity). Interacts with LAYN (PubMed:15913605). Interacts with NHERF1 and NHERF2 (PubMed:16615918). Interacts with MME/NEP (PubMed:17459884). Interacts with ICAM2 (PubMed:12554651, PubMed:9472040). Interacts (via FERM domain) with SPN/CD43 cytoplasmic tail (PubMed:18614175, PubMed:9472040). Interacts with CD44 (PubMed:9472040). Interacts with CLIC5; may work together in a complex which also includes EZR and MYO6 to stabilize linkages between the plasma membrane and subjacent actin cytoskeleton at the base of stereocilia (PubMed:24285636).INTERACTION Enriched at the stereocilium base with very low levels in the shaft of stereociliary bundles (PubMed:30159668). Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively.DOMAIN The N-terminal domain interacts with the C-terminal domain of LAYN. An interdomain interaction between its N-terminal and C-terminal domains inhibits its ability to bind LAYN. In the presence of acidic phospholipids, the interdomain interaction is inhibited and this enhances binding to LAYN.PTM Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding. |
| description | recommendedName: Radixin alternativeName: ESP10 |
| geneName | Rdx |
| identifier | P26043 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Actin capping Actin-binding Cell membrane Cell projection Cytoplasm Cytoskeleton Direct protein sequencing Membrane Phosphoprotein Reference proteome |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5083144] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:5691543] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9607352] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9767224] Weiser, Joel [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | Rdx |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | RADI_MOUSE Q3TS85 Q9QW27 |
| sequenceLength | 583 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9662388] p-T564-Rdx [cytosol] [Mus musculus] [EntityWithAccessionedSequence:9670540] Rdx [cytosol] [Mus musculus] |
| (referenceSequence) | [ModifiedResidue:9662926] O-phospho-L-threonine at 564 |
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No pathways have been reviewed or authored by UniProt:P26043 Rdx (99595)
