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Details on Person Studies with the mouse mammary epithelial cell line HC11 sho...

Class:IdSummation:9959479
_displayNameStudies with the mouse mammary epithelial cell line HC11 sho...
_timestamp2025-12-01 16:54:56
created[InstanceEdit:9959480] Orlic-Milacic, Marija, 2025-06-30
literatureReference[LiteratureReference:9958818] Activated Rac1 requires gp130 for Stat3 activation, cell proliferation and migration
[LiteratureReference:9958805] Cadherin-cadherin engagement promotes cell survival via Rac1/Cdc42 and signal transducer and activator of transcription-3
[LiteratureReference:9968047] Proteasome-mediated degradation of Rac1-GTP during epithelial cell scattering
modified[InstanceEdit:9968048] Orlic-Milacic, Marija, 2025-10-08
[InstanceEdit:9975419] Orlic-Milacic, Marija, 2025-12-01
textStudies with the mouse mammary epithelial cell line HC11 showed that CDH1 engagement triggers a dramatic surge in total RAC1 and CDC42 protein levels and activity through inhibition of proteolytic degradation by the 26S proteasome (Arulanandam et al. 2009, Arulanandam et al. 2010). In Madin Darby canine kidney II (MDCKII) cell line, the dissolution of CDH1 adhesions triggers cell scattering which is accompanied by RAC1 ubiquitination and proteasome-mediated degradation (Lynch et al. 2006).
(summation)[BlackBoxEvent:9958874] 26S proteasome degrades ubiquitinated RAC1, CDC42 [Homo sapiens]
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