Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person DISPUTED BY AUTHORS: Cell-to-cell contact through homophilic cadherin interactions promotes transient RAC1,(CDC42) activation

Class:Id	BlackBoxEvent:9959445
_displayName	DISPUTED BY AUTHORS: Cell-to-cell contact through homophilic cadherin interactions promotes transient RAC1,(CDC42) activation
_doRelease	FALSE
_timestamp	2025-10-28 15:48:04
catalystActivity	[CatalystActivity:9959439] guanyl-nucleotide exchange factor activity of (Cadherin engagement/SRC-activated RHO GEFs) [cytosol]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9959440] Orlic-Milacic, Marija, 2025-06-30
input	[CandidateSet:9959442] RAC1:GDP,(CDC42:GDP) [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:445346] Cadherin engagement regulates Rho family GTPases [LiteratureReference:9967765] Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells [LiteratureReference:9967775] Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation [LiteratureReference:9967787] E-cadherin-mediated cell-cell attachment activates Cdc42 [LiteratureReference:9967795] Co-localization of Rac1 and E-cadherin in human epidermal keratinocytes [LiteratureReference:9967780] Newly formed E-cadherin contacts do not activate Cdc42 or induce filopodia protrusion in human keratinocytes [LiteratureReference:9967789] Cooperation of distinct Rac-dependent pathways to stabilise E-cadherin adhesion [LiteratureReference:9967885] HOXC8-Dependent Cadherin 11 Expression Facilitates Breast Cancer Cell Migration through Trio and Rac [LiteratureReference:9967829] Rac1 mediates cadherin-11 induced cellular pathogenic processes in aortic valve calcification
modified	[InstanceEdit:9959451] Orlic-Milacic, Marija, 2025-06-30 [InstanceEdit:9959481] Orlic-Milacic, Marija, 2025-06-30 [InstanceEdit:9959484] Orlic-Milacic, Marija, 2025-06-30 [InstanceEdit:9962475] Orlic-Milacic, Marija, 2025-08-06 [InstanceEdit:9963952] Orlic-Milacic, Marija, 2025-08-18 [InstanceEdit:9967779] Orlic-Milacic, Marija, 2025-10-06 [InstanceEdit:9967799] Orlic-Milacic, Marija, 2025-10-07 [InstanceEdit:9967916] Orlic-Milacic, Marija, 2025-10-07 [InstanceEdit:9968581] Orlic-Milacic, Marija, 2025-10-16 [InstanceEdit:9970158] Orlic-Milacic, Marija, 2025-10-28
name	DISPUTED BY AUTHORS: Cell-to-cell contact through homophilic cadherin interactions promotes transient RAC1,(CDC42) activation
output	[CandidateSet:9959034] RAC1:GTP,(CDC42:GTP) [plasma membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:9934410] CDH1 forms homotypic trans-dimers [Homo sapiens] [Reaction:9934486] CDH1-associated CTNNA1 binds F-actin [Homo sapiens] [Reaction:9934294] CDH1-associated CTNNA1 binds VCL [Homo sapiens] [Reaction:9833674] CDH11 forms homotypic trans dimers [Homo sapiens]
regulatedBy	[PositiveRegulation:9959443] Positive regulation by 'Engaged CDH1,(CDH11) [plasma membrane]'
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9959447] R-HSA-9959445.1
summation	[Summation:9959483] AUTHORS DISPUTED THIS EVENT ALTHOUGH ORIGINALLY PROPOSING...
(replacementInstances)	[_Deleted:9959454] Deletion of instance: 9958876
[Change default viewing format]

No pathways have been reviewed or authored by DISPUTED BY AUTHORS: Cell-to-cell contact through homophilic cadherin interactions promotes transient RAC1,(CDC42) activation (9959445)