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Details on Person Interleukin-6 (IL6) activates the tyrosine phosphorylation o...
| Class:Id | Summation:9958927 |
|---|---|
| _displayName | Interleukin-6 (IL6) activates the tyrosine phosphorylation o... |
| _timestamp | 2025-06-25 22:44:20 |
| created | [InstanceEdit:9958929] Orlic-Milacic, Marija, 2025-06-25 |
| text | Interleukin-6 (IL6) activates the tyrosine phosphorylation of STATs (Akira et al. 1994, Zhong et al. 1994) by receptor-associated JAKs (Hemmann et al. 1996) at a site that is essential for dimerization. For STAT3 this is tyrosine-705 (Kaptein et al. 1996, Shuai et al. 1994). Tyrosine phosphorylation leads to homo- or heterodimerization and translocation to the nucleus (Zhong et al. 1994), where the STAT dimers bind to enhancers of IL6- inducible genes e.g. acute phase protein genes, resulting in transcriptional activation. |
| (summation) | [Reaction:9958871] Tyrosine phosphorylation of STAT3 by IL6 receptor [Homo sapiens] |
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