Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person Diagram of Activation of STAT3 by cadherin engagement

Class:IdPathwayDiagram:9958925
_displayNameDiagram of Activation of STAT3 by cadherin engagement
_timestamp2026-03-03 13:10:10
created[InstanceEdit:9958924] Orlic-Milacic, Marija, 2025-06-25
height2174
modified[InstanceEdit:9958935] Orlic-Milacic, Marija, 2025-06-25
[InstanceEdit:9958936] Orlic-Milacic, Marija, 2025-06-25
[InstanceEdit:9959037] Orlic-Milacic, Marija, 2025-06-26
[InstanceEdit:9959208] Orlic-Milacic, Marija, 2025-06-26
[InstanceEdit:9959450] Orlic-Milacic, Marija, 2025-06-30
[InstanceEdit:9959451] Orlic-Milacic, Marija, 2025-06-30
[InstanceEdit:9959472] Orlic-Milacic, Marija, 2025-06-30
[InstanceEdit:9959473] Orlic-Milacic, Marija, 2025-06-30
[InstanceEdit:9959474] Orlic-Milacic, Marija, 2025-06-30
[InstanceEdit:9959475] Orlic-Milacic, Marija, 2025-06-30
[InstanceEdit:9959478] Orlic-Milacic, Marija, 2025-06-30
[InstanceEdit:9959485] Orlic-Milacic, Marija, 2025-06-30
[InstanceEdit:9959813] Orlic-Milacic, Marija, 2025-07-02
[InstanceEdit:9965679] Orlic-Milacic, Marija, 2025-09-04
[InstanceEdit:9967735] Orlic-Milacic, Marija, 2025-10-06
[InstanceEdit:9967948] Orlic-Milacic, Marija, 2025-10-08
[InstanceEdit:9967949] Orlic-Milacic, Marija, 2025-10-08
[InstanceEdit:9967954] Orlic-Milacic, Marija, 2025-10-08
[InstanceEdit:9967955] Orlic-Milacic, Marija, 2025-10-08
[InstanceEdit:9967956] Orlic-Milacic, Marija, 2025-10-08
[InstanceEdit:9968030] Orlic-Milacic, Marija, 2025-10-08
[InstanceEdit:9968042] Orlic-Milacic, Marija, 2025-10-08
[InstanceEdit:9968048] Orlic-Milacic, Marija, 2025-10-08
[InstanceEdit:9968054] Orlic-Milacic, Marija, 2025-10-08
[InstanceEdit:9968112] Orlic-Milacic, Marija, 2025-10-09
[InstanceEdit:9968183] Orlic-Milacic, Marija, 2025-10-10
[InstanceEdit:9968574] Orlic-Milacic, Marija, 2025-10-16
[InstanceEdit:9968587] Orlic-Milacic, Marija, 2025-10-16
[InstanceEdit:9968601] Orlic-Milacic, Marija, 2025-10-17
[InstanceEdit:9968618] Orlic-Milacic, Marija, 2025-10-17
[InstanceEdit:9970159] Orlic-Milacic, Marija, 2025-10-28
[InstanceEdit:9970168] Orlic-Milacic, Marija, 2025-10-28
[InstanceEdit:9970169] Orlic-Milacic, Marija, 2025-10-28
[InstanceEdit:9970171] Orlic-Milacic, Marija, 2025-10-28
[InstanceEdit:9975420] Orlic-Milacic, Marija, 2025-12-01
[InstanceEdit:9981830] Orlic-Milacic, Marija, 2026-02-11
[InstanceEdit:9983945] Orlic-Milacic, Marija, 2026-03-02
[InstanceEdit:9984073] Orlic-Milacic, Marija, 2026-03-03
representedPathway[Pathway:9958825] Activation of STAT3 by cadherin engagement [Homo sapiens]
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<displayName>RAC1:GDP,(CDC42:GDP)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="1188" reactomeId="9959444" position="395 605" bounds="296 594 198 23" textPosition="321 594" bgColor="204 255 255" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>Engaged CDH1,(CDH11)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="1422" reactomeId="9959465" position="578 480" bounds="527 462 102 36" textPosition="527 462" bgColor="204 255 255" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>Ub-RAC1:GTP,(Ub-CDC42:GTP)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="1423" reactomeId="9959457" position="687 612" bounds="650 580 75 64" textPosition="655 580"> <Properties> <displayName>RAC1,(CDC42) Ubiquitin Ligase</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="1425" reactomeId="113595" position="677 372" bounds="658 361 38 23" textPosition="665 361"> <Properties> <displayName>Ub</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1442" reactomeId="68819" position="695 490" bounds="654 472 82 36" textPosition="655 472" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>26S proteasome</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="3084" reactomeId="9968091" position="822 1433" bounds="772 1411 101 45" textPosition="776 1409"> <Properties> <displayName>SRC targeted RAC1/CDC42 GEFs</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="3085" reactomeId="9968090" position="765 1197" bounds="712 1168 106 59" textPosition="712 1166"> <Properties> <displayName>SRC-phosphorylated RAC1/CDC42 GEFs</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="3086" reactomeId="113592" position="697 1338" bounds="677 1328 41 21" textPosition="682 1328" /> <org.gk.render.RenderableChemical id="3087" reactomeId="29370" position="837 1262" bounds="816 1252 43 20" textPosition="821 1251" /> <org.gk.render.RenderableGene id="3156" reactomeId="3788729" position="969 662" bounds="937 636 64 52" textPosition="940 663"> <Properties> <displayName>IL6 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableEntitySet id="3296" reactomeId="1067656" position="922 409" bounds="899 389 47 40" textPosition="900 384"> <Properties> <displayName>JAK1, JAK2, (TYK2)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="3297" reactomeId="448453" position="880 299" bounds="859 287 42 25" textPosition="860 288"> <Properties> <displayName>IL6ST</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.Note id="4844" position="911 485" bounds="858 471 106 29" textPosition="860 474"> <Properties> <displayName>Downregulation</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.Note> <org.gk.render.RenderableChemical id="4999" reactomeId="29438" position="688 1060" bounds="668 1048 40 25" textPosition="673 1049"> <Properties> <displayName>GTP</displayName> </Properties> <Shortcuts> <Shortcut id="4999" /> <Shortcut id="5308" /> </Shortcuts> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="5015" reactomeId="29420" position="819 931" bounds="803 922 32 19" textPosition="803 921"> <Properties> <displayName>GDP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="5048" reactomeId="9934368" position="717 799" bounds="654 788 126 23" textPosition="679 788"> <Properties> <displayName>CTNNB1,JUP</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="5133" reactomeId="191697" position="736 842" bounds="706 831 61 23" textPosition="707 831" /> <org.gk.render.RenderableProtein id="5135" reactomeId="418996" position="564 908" bounds="535 897 58 23" textPosition="535 897"> <Properties> <displayName>CTNND1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="5137" reactomeId="113595" position="851 760" bounds="832 749 38 23" textPosition="839 749" /> <org.gk.render.RenderableComplex id="5138" reactomeId="9681293" position="916 25" bounds="853 12 126 26" textPosition="856 16" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>IL6R:IL6R inhibitors</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="5139" reactomeId="1067674" position="1057 85" bounds="997 75 120 21" textPosition="1000 74" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>IL6:IL6R-2:IL6ST-2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="5155" reactomeId="6783589" position="1073 475" bounds="987 439 173 72" textPosition="1008 453"> <Properties> <displayName>Interleukin-6 family signaling</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableChemical id="5308" reactomeId="29438" position="735 434" bounds="715 422 40 25" textPosition="720 423" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="2" reactomeId="1067667" points="800 86, 915 91, 895 257" position="915 91" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" points="799 264" /> <Input id="4" points="691 216, 665 125" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> <Inhibitors> <Inhibitor id="5138" points="915 41" /> </Inhibitors> <Properties> <displayName>IL6 binds IL6R</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="6" reactomeId="1067640" points="755 216, 787 209, 831 186" position="787 209" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="7" points="731 184" /> <Input id="4" points="721 223" /> </Inputs> <Outputs> <Output id="8" /> </Outputs> <Properties> <displayName>IL6 binds IL6R-2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9" reactomeId="1067688" points="1024 219, 1064 234, 1108 294" position="1064 234" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="5" points="921 257" /> <Input id="10" points="1019 259" /> </Inputs> <Outputs> <Output id="11" /> </Outputs> <Properties> <displayName>IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="12" reactomeId="1067651" points="967 210, 1057 184, 1191 292" position="1057 184" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="8" points="883 186" /> <Input id="10" points="997 259" /> </Inputs> <Outputs> <Output id="13" /> </Outputs> <Inhibitors> <Inhibitor id="5139" points="1057 99" /> </Inhibitors> <Properties> <displayName>IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14" reactomeId="1067659" points="1450 301, 1515 304, 1576 305" position="1515 304" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="15" stoichiometry="2" /> </Inputs> <Outputs> <Output id="16" /> </Outputs> <Properties> <displayName>Assembly of hexameric IL-6 receptor</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="17" points="1254 310, 1338 302" position="1296 306" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="13" /> </Inputs> <Outputs> <Output id="15" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="18" points="1134 335, 1177 388, 1352 322" position="1177 388" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="11" /> </Inputs> <Outputs> <Output id="15" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="19" reactomeId="1112514" points="1709 299, 1735 302, 1753 301" position="1735 302" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="16" points="1681 301" /> <Input id="20" stoichiometry="12" points="1682 370" /> </Inputs> <Outputs> <Output id="21" stoichiometry="12" points="1772 368" /> <Output id="22" points="1777 303" /> </Outputs> <Properties> <displayName>JAK activation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="38" reactomeId="1112510" points="1920 297, 1945 300, 1974 298" position="1945 300" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="22" points="1887 301" /> <Input id="39" stoichiometry="20" points="1905 369" /> </Inputs> <Outputs> <Output id="40" stoichiometry="20" points="1993 380" /> <Output id="41" points="2011 299" /> </Outputs> <Properties> <displayName>IL6ST is tyrosine phosphorylated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="135" reactomeId="9958878" points="2091 400, 2086 457, 2093 543" position="2086 457" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="136" points="2058 418" /> <Input id="41" points="2081 338" /> </Inputs> <Outputs> <Output id="137" /> </Outputs> <Properties> <displayName>Tyrosine phosphorylated IL6ST binds STAT3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="168" reactomeId="9958871" points="2119 651, 2118 682, 2113 715" position="2118 682" lineWidth="1.0"> <Inputs> <Input id="137" points="2106 614" /> <Input id="169" points="2078 651" /> </Inputs> <Outputs> <Output id="170" points="2067 711" /> <Output id="171" points="2106 743" /> </Outputs> <Catalysts> <Catalyst id="137" points="2117 614, 2162 679" /> </Catalysts> <Properties> <displayName>Tyrosine phosphorylation of STAT3 by IL6 receptor</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="187" reactomeId="9958877" points="2029 743, 1913 698, 1887 640" position="1913 698" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="171" /> </Inputs> <Outputs> <Output id="41" points="2057 338" /> <Output id="188" points="1824 638" /> </Outputs> <Properties> <displayName>p-Y705-STAT3 dissociates from IL6 receptor</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="341" reactomeId="9958889" points="421 1571, 424 1609, 421 1652" position="424 1609" lineWidth="1.0"> <Inputs> <Input id="342" stoichiometry="10" points="480 1563" /> <Input id="343" points="445 1536" /> </Inputs> <Outputs> <Output id="344" stoichiometry="10" points="631 1695" /> <Output id="345" stoichiometry="2" points="647 1656" /> <Output id="346" points="431 1723" /> <Output id="347" points="632 1604" /> </Outputs> <Catalysts> <Catalyst id="348" points="393 1446, 350 1461, 350 1609" /> </Catalysts> <Properties> <displayName>SRC phosphorylates CDH1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="379" reactomeId="9934755" points="428 1799, 429 1825, 419 1869" position="429 1825" lineWidth="1.0"> <Inputs> <Input id="380" stoichiometry="2" points="513 1811" /> <Input id="346" points="431 1778" /> </Inputs> <Outputs> <Output id="381" stoichiometry="2" points="503 1872" /> <Output id="382" stoichiometry="2" points="419 1937" /> </Outputs> <Properties> <displayName>CBLL1 binds p-Y-CDH1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="398" reactomeId="9934753" points="432 1994, 436 2026, 440 2069" position="436 2026" lineWidth="1.0"> <Inputs> <Input id="399" stoichiometry="6" points="636 1933" /> <Input id="382" points="422 1962" /> </Inputs> <Outputs> <Output id="400" /> </Outputs> <Catalysts> <Catalyst id="382" points="412 1962, 377 2001" /> </Catalysts> <Properties> <displayName>CBLL1 ubiquitinates CDH1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="401" reactomeId="9934752" points="524 2082, 615 2080, 694 2030" position="615 2080" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="400" /> </Inputs> <Outputs> <Output id="402" /> </Outputs> <Properties> <displayName>Ubiquitinated CDH1 is endocytosed</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="404" reactomeId="9935552" points="723 1987, 731 1870, 812 1866" position="731 1870" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="402" /> </Inputs> <Outputs> <Output id="405" /> </Outputs> <Properties> <displayName>Ubiquitinated CDH1 translocates to lysosomes for degradation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="407" reactomeId="9935547" points="838 1845, 732 1819, 633 1819" position="732 1819" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="405" /> </Inputs> <Outputs> <Output id="380" /> </Outputs> <Catalysts> <Catalyst id="408" points="896 1793" /> </Catalysts> <Properties> <displayName>Lysosomal degradation of ubiquitinated CDH1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="756" reactomeId="9958872" points="881 712, 928 716, 983 715" position="928 716" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="757" /> </Inputs> <Outputs> <Output id="758" /> </Outputs> <Activators> <Activator id="759" points="677 941, 826 899" /> </Activators> <Properties> <displayName>RAC1, CDC42 activate NFκB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="995" reactomeId="9934410" points="357 973, 361 941, 365 900" position="361 941" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="996" stoichiometry="120" points="365 1061" /> <Input id="997" points="299 1003" /> <Input id="998" points="400 987" /> </Inputs> <Outputs> <Output id="999" /> </Outputs> <Properties> <displayName>CDH1 forms homotypic trans-dimers</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1000" reactomeId="9934411" points="495 1466, 559 1415, 453 1365" position="559 1415" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="343" stoichiometry="5" /> </Inputs> <Outputs> <Output id="1001" /> </Outputs> <Properties> <displayName>CDH1 forms cis-clusters</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1002" reactomeId="9934486" points="454 1272, 443 1242, 430 1205" position="443 1242" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1001" points="428 1326" /> <Input id="1003" stoichiometry="5" points="658 1276" /> </Inputs> <Outputs> <Output id="1004" /> </Outputs> <Properties> <displayName>CDH1-associated CTNNA1 binds F-actin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1005" reactomeId="9934294" points="458 1116, 456 1098, 452 1033" position="456 1098" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1006" stoichiometry="5" points="652 1182" /> <Input id="1004" points="433 1161" /> </Inputs> <Outputs> <Output id="998" /> </Outputs> <Properties> <displayName>CDH1-associated CTNNA1 binds VCL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1023" interactionType="Activate" points="640 1507, 556 1503" position="598 1505" lineWidth="2.0"> <Inputs> <Input id="1022" /> </Inputs> <Outputs> <Output id="343" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1072" reactomeId="9833674" points="373 750, 370 724, 375 695" position="370 724" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1073" points="310 780" /> <Input id="1074" points="418 758" /> <Input id="1077" stoichiometry="24" points="380 811" /> </Inputs> <Outputs> <Output id="1076" /> </Outputs> <Properties> <displayName>CDH11 forms homotypic trans dimers</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="1189" points="443 875, 581 870, 586 688, 421 623" position="583 779" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="999" /> </Inputs> <Outputs> <Output id="1188" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1190" points="383 655, 392 623" position="387 639" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1076" /> </Inputs> <Outputs> <Output id="1188" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="1441" reactomeId="9958874" points="595 456, 644 411, 692 415" position="644 411" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="1422" /> </Inputs> <Outputs> <Output id="1425" points="712 425" /> <Output id="5308" points="681 390" /> </Outputs> <Catalysts> <Catalyst id="1442" points="683 469" /> </Catalysts> <Properties> <displayName>26S proteasome degrades ubiquitinated RAC1, CDC42</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1874" reactomeId="2730595" points="1716 636, 1664 636, 1612 764" position="1664 636" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="188" stoichiometry="2" /> </Inputs> <Outputs> <Output id="190" /> </Outputs> <Properties> <displayName>Phosphorylated STAT3 Forms Dimers</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1875" reactomeId="2730599" points="1539 777, 1200 772, 1141 772" position="1200 772" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="190" /> </Inputs> <Outputs> <Output id="192" /> </Outputs> <Properties> <displayName>Phosphorylated STAT3 Dimer Translocates to the Nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2732" reactomeId="9958891" points="497 812, 522 853, 598 856" position="522 853" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="1074" /> </Inputs> <Outputs> <Output id="5048" points="692 817" /> <Output id="5133" points="703 845" /> <Output id="5135" points="571 894" /> </Outputs> <Activators> <Activator id="348" points="471 1400, 549 1351" /> </Activators> <Properties> <displayName>SRC downregulates CDH11</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3083" reactomeId="9958892" points="680 1433, 685 1434, 768 1308" position="685 1434" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="3084" points="766 1433" /> <Input id="3086" points="695 1352" /> </Inputs> <Outputs> <Output id="3087" points="822 1275" /> <Output id="3085" points="765 1233" /> </Outputs> <Catalysts> <Catalyst id="348" points="497 1425" /> </Catalysts> <Properties> <displayName>SRC promotes RAC1 and CDC42 activation by phosphorylating RAC1 and CDC42 GEFs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3138" reactomeId="9958873" points="794 769, 601 761, 599 628, 580 504" position="599 628" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="759" points="656 933, 793 869" /> <Input id="5137" stoichiometry="3" points="826 763" /> </Inputs> <Outputs> <Output id="1422" /> </Outputs> <Catalysts> <Catalyst id="1423" points="644 618" /> </Catalysts> <Inhibitors> <Inhibitor id="1188" points="500 616" /> </Inhibitors> <Properties> <displayName>Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3155" reactomeId="9958869" points="1064 677, 1099 666, 1082 626" position="1099 666" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="758" points="1054 700" /> <Input id="3156" points="1010 638" /> </Inputs> <Outputs> <Output id="811" /> </Outputs> <Properties> <displayName>Activated NFκB complex binds IL6 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3157" reactomeId="9958875" points="1010 638, 926 562, 836 543, 698 240" position="926 562" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="3156" /> </Inputs> <Outputs> <Output id="4" /> </Outputs> <Activators> <Activator id="811" points="1022 588" /> </Activators> <Properties> <displayName>NFκB stimulates IL6 gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3295" reactomeId="1067646" points="905 343, 949 314, 986 301" position="949 314" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3296" points="916 383" /> <Input id="3297" points="887 315" /> </Inputs> <Outputs> <Output id="10" /> </Outputs> <Properties> <displayName>JAK1,JAK2,(TYK2) bind IL6ST</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4813" reactomeId="9968598" points="872 315, 854 345, 893 464" position="854 345" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="3297" /> </Inputs> <Inhibitors> <Inhibitor id="1188" points="433 623, 722 703, 800 341" /> </Inhibitors> <Properties> <displayName>CDH1,CDH11 promote stabilization of IL6ST protein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4998" reactomeId="9970163" points="738 1110, 741 1051, 741 1029" position="741 1051" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="4999" points="700 1076" /> <Input id="1184" points="686 1111" /> </Inputs> <Outputs> <Output id="759" points="649 976" /> <Output id="5015" points="811 944" /> </Outputs> <Catalysts> <Catalyst id="3085" points="760 1162" /> </Catalysts> <Properties> <displayName>SRC-phosphorylated RAC1,(CDC42) GEFs activate RAC1,(CDC42)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="5156" interactionType="Activate" points="1061 436, 1025 327" position="1043 381" lineWidth="2.0"> <Inputs> <Input id="5155" /> </Inputs> <Outputs> <Output id="10" /> </Outputs> </org.gk.render.RenderableInteraction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Activation of STAT3 by cadherin engagement (9958925)
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