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Details on Person SRC promotes RAC1 and CDC42 activation by phosphorylating RAC1 and CDC42 GEFs

Class:Id	BlackBoxEvent:9958892
_displayName	SRC promotes RAC1 and CDC42 activation by phosphorylating RAC1 and CDC42 GEFs
_doRelease	TRUE
_timestamp	2026-03-09 13:26:32
authored	[InstanceEdit:9958890] Orlic-Milacic, Marija, 2025-06-25
catalystActivity	[CatalystActivity:8876946] protein tyrosine kinase activity of MyrG-p-Y419-SRC [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9958890] Orlic-Milacic, Marija, 2025-06-25
edited	[InstanceEdit:9984139] Orlic-Milacic, Marija, 2026-03-03
input	[CandidateSet:9968091] SRC targeted RAC1/CDC42 GEFs [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9644203] Phosphorylation and activation of the Rac1 and Cdc42 GEF Asef in A431 cells stimulated by EGF [LiteratureReference:5218543] VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2 [LiteratureReference:9968182] Autocrine VEGF and IL-8 Promote Migration via Src/Vav2/Rac1/PAK1 Signaling in Human Umbilical Vein Endothelial Cells [LiteratureReference:9968517] The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1 [LiteratureReference:9968535] Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis
modified	[InstanceEdit:9968097] Orlic-Milacic, Marija, 2025-10-09 [InstanceEdit:9968112] Orlic-Milacic, Marija, 2025-10-09 [InstanceEdit:9968124] Orlic-Milacic, Marija, 2025-10-09 [InstanceEdit:9968176] Orlic-Milacic, Marija, 2025-10-10 [InstanceEdit:9968183] Orlic-Milacic, Marija, 2025-10-10 [InstanceEdit:9968478] Orlic-Milacic, Marija, 2025-10-14 [InstanceEdit:9968523] Orlic-Milacic, Marija, 2025-10-14 [InstanceEdit:9968542] Orlic-Milacic, Marija, 2025-10-15 [InstanceEdit:9968580] Orlic-Milacic, Marija, 2025-10-16 [InstanceEdit:9968581] Orlic-Milacic, Marija, 2025-10-16 [InstanceEdit:9975426] Orlic-Milacic, Marija, 2025-12-01 [InstanceEdit:9984518] Orlic-Milacic, Marija, 2026-03-09
name	SRC promotes RAC1 and CDC42 activation by phosphorylating RAC1 and CDC42 GEFs
output	[CandidateSet:9968090] SRC-phosphorylated RAC1/CDC42 GEFs [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
releaseDate	2026-03-25
reviewed	[InstanceEdit:9975417] Raptis, Leda, 2025-11-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9958893] R-HSA-9958892.1
structureModified	[InstanceEdit:9968097] Orlic-Milacic, Marija, 2025-10-09 [InstanceEdit:9968112] Orlic-Milacic, Marija, 2025-10-09
summation	[Summation:9968085] SRC promotes RAC1 activation primarily through tyrosine p...
(hasEvent)	[Pathway:9958810] SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9970163] SRC-phosphorylated RAC1,(CDC42) GEFs activate RAC1,(CDC42) [Homo sapiens]
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No pathways have been reviewed or authored by SRC promotes RAC1 and CDC42 activation by phosphorylating RAC1 and CDC42 GEFs (9958892)