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Details on Person SRC phosphorylates CDH1

Class:Id	Reaction:9958889
_displayName	SRC phosphorylates CDH1
_doRelease	TRUE
_timestamp	2026-03-09 13:26:28
authored	[InstanceEdit:9958870] Orlic-Milacic, Marija, 2025-06-25
catalystActivity	[CatalystActivity:8876946] protein tyrosine kinase activity of MyrG-p-Y419-SRC [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9958890] Orlic-Milacic, Marija, 2025-06-25
edited	[InstanceEdit:9984139] Orlic-Milacic, Marija, 2026-03-03
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [DefinedSet:9934398] Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:CTNND1 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9762164] Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription [LiteratureReference:9935502] Cdc42 regulates E-cadherin ubiquitination and degradation through an epidermal growth factor receptor to Src-mediated pathway [LiteratureReference:9934839] An acidic extracellular pH disrupts adherens junctions in HepG2 cells by Src kinases-dependent modification of E-cadherin [LiteratureReference:9935530] Basolateral CD147 induces hepatocyte polarity loss by E-cadherin ubiquitination and degradation in hepatocellular carcinoma progress [LiteratureReference:9935068] Rack1 promotes epithelial cell-cell adhesion by regulating E-cadherin endocytosis
modified	[InstanceEdit:9958936] Orlic-Milacic, Marija, 2025-06-25 [InstanceEdit:9959488] Orlic-Milacic, Marija, 2025-06-30 [InstanceEdit:9962475] Orlic-Milacic, Marija, 2025-08-06 [InstanceEdit:9963952] Orlic-Milacic, Marija, 2025-08-18 [InstanceEdit:9968581] Orlic-Milacic, Marija, 2025-10-16 [InstanceEdit:9975426] Orlic-Milacic, Marija, 2025-12-01 [InstanceEdit:9975763] Orlic-Milacic, Marija, 2025-12-02 [InstanceEdit:9984518] Orlic-Milacic, Marija, 2026-03-09
name	SRC phosphorylates CDH1
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [EntityWithAccessionedSequence:191697] CTNNA1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:191697] CTNNA1 [cytosol] [Homo sapiens] [DefinedSet:9934825] Man,Man9GlucNAc2,p-3S,2Y-CDH1:p-Y-CTNND1 [plasma membrane] [Homo sapiens] [DefinedSet:9935537] p-Y-CTNNB1,p-Y-JUP [cytosol] [Homo sapiens]
releaseDate	2026-03-25
reviewed	[InstanceEdit:9975417] Raptis, Leda, 2025-11-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9958894] R-HSA-9958889.1
structureModified	[InstanceEdit:9958936] Orlic-Milacic, Marija, 2025-06-25
summation	[Summation:9959486] In the canine MDCK cell line, CDH1 (E-cadherin) and CTNNB...
(hasEvent)	[Pathway:9958810] SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) [Homo sapiens]
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