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Details on Person Tyrosine phosphorylated IL6ST binds STAT3

Class:Id	Reaction:9958878
_displayName	Tyrosine phosphorylated IL6ST binds STAT3
_doRelease	TRUE
_timestamp	2026-03-09 13:26:39
authored	[InstanceEdit:9958914] Orlic-Milacic, Marija, 2025-06-25
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9958870] Orlic-Milacic, Marija, 2025-06-25
edited	[InstanceEdit:9984139] Orlic-Milacic, Marija, 2026-03-03
input	[Complex:1112594] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:539044] STAT3 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1112531] Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation [LiteratureReference:1112547] Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation
modified	[InstanceEdit:9958935] Orlic-Milacic, Marija, 2025-06-25 [InstanceEdit:9962475] Orlic-Milacic, Marija, 2025-08-06 [InstanceEdit:9963952] Orlic-Milacic, Marija, 2025-08-18 [InstanceEdit:9968581] Orlic-Milacic, Marija, 2025-10-16 [InstanceEdit:9975420] Orlic-Milacic, Marija, 2025-12-01 [InstanceEdit:9983956] Orlic-Milacic, Marija, 2026-03-02 [InstanceEdit:9984518] Orlic-Milacic, Marija, 2026-03-09
name	Tyrosine phosphorylated IL6ST binds STAT3
output	[Complex:9958926] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT3 [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:1112510] IL6ST is tyrosine phosphorylated [Homo sapiens] [BlackBoxEvent:1112514] JAK activation [Homo sapiens]
releaseDate	2026-03-25
reviewed	[InstanceEdit:9975417] Raptis, Leda, 2025-11-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9958887] R-HSA-9958878.1
structureModified	[InstanceEdit:9958935] Orlic-Milacic, Marija, 2025-06-25
summation	[Summation:9958932] STAT3 binds to IL6ST (gp130) via phosphotyrosine residues 90...
(hasEvent)	[Pathway:9958825] Activation of STAT3 by cadherin engagement [Homo sapiens]
(precedingEvent)	[Reaction:9958871] Tyrosine phosphorylation of STAT3 by IL6 receptor [Homo sapiens]
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No pathways have been reviewed or authored by Tyrosine phosphorylated IL6ST binds STAT3 (9958878)