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Details on Person p-Y705-STAT3 dissociates from IL6 receptor

Class:Id	Reaction:9958877
_displayName	p-Y705-STAT3 dissociates from IL6 receptor
_doRelease	TRUE
_timestamp	2026-03-09 13:26:47
authored	[InstanceEdit:9958922] Orlic-Milacic, Marija, 2025-06-25
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9958870] Orlic-Milacic, Marija, 2025-06-25
edited	[InstanceEdit:9984139] Orlic-Milacic, Marija, 2026-03-03
input	[Complex:9958930] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:p-Y705-STAT3 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1112522] Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
modified	[InstanceEdit:9958935] Orlic-Milacic, Marija, 2025-06-25 [InstanceEdit:9962475] Orlic-Milacic, Marija, 2025-08-06 [InstanceEdit:9963952] Orlic-Milacic, Marija, 2025-08-18 [InstanceEdit:9968581] Orlic-Milacic, Marija, 2025-10-16 [InstanceEdit:9975420] Orlic-Milacic, Marija, 2025-12-01 [InstanceEdit:9984518] Orlic-Milacic, Marija, 2026-03-09
name	p-Y705-STAT3 dissociates from IL6 receptor
output	[Complex:1112594] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:914048] p-Y705-STAT3 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9958871] Tyrosine phosphorylation of STAT3 by IL6 receptor [Homo sapiens] [Reaction:9958878] Tyrosine phosphorylated IL6ST binds STAT3 [Homo sapiens]
releaseDate	2026-03-25
reviewed	[InstanceEdit:9975417] Raptis, Leda, 2025-11-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9958881] R-HSA-9958877.1
structureModified	[InstanceEdit:9958935] Orlic-Milacic, Marija, 2025-06-25
summation	[Summation:9958928] Following phosphorylation, STAT3 is released from the IL6 re...
(hasEvent)	[Pathway:9958825] Activation of STAT3 by cadherin engagement [Homo sapiens]
(precedingEvent)	[Reaction:2730595] Phosphorylated STAT3 Forms Dimers [Homo sapiens] [BlackBoxEvent:6784765] p-Y705-STAT3 dimerizes [Homo sapiens]
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No pathways have been reviewed or authored by p-Y705-STAT3 dissociates from IL6 receptor (9958877)