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Details on Person RAC1, CDC42 activate NFκB

Class:IdBlackBoxEvent:9958872
_displayNameRAC1, CDC42 activate NFκB
_doReleaseTRUE
_timestamp2026-03-09 13:26:11
authored[InstanceEdit:9958890] Orlic-Milacic, Marija, 2025-06-25
compartment[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
created[InstanceEdit:9958870] Orlic-Milacic, Marija, 2025-06-25
edited[InstanceEdit:9984139] Orlic-Milacic, Marija, 2026-03-03
input[Complex:194043] NFKB1(1-433):RELA [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9958904] ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation
[LiteratureReference:9958918] RAC1b overexpression stimulates proliferation and NF-kB-mediated anti-apoptotic signaling in thyroid cancer cells
modified[InstanceEdit:9958914] Orlic-Milacic, Marija, 2025-06-25
[InstanceEdit:9959006] Orlic-Milacic, Marija, 2025-06-26
[InstanceEdit:9959037] Orlic-Milacic, Marija, 2025-06-26
[InstanceEdit:9959451] Orlic-Milacic, Marija, 2025-06-30
[InstanceEdit:9962475] Orlic-Milacic, Marija, 2025-08-06
[InstanceEdit:9963952] Orlic-Milacic, Marija, 2025-08-18
[InstanceEdit:9968581] Orlic-Milacic, Marija, 2025-10-16
[InstanceEdit:9975419] Orlic-Milacic, Marija, 2025-12-01
[InstanceEdit:9984518] Orlic-Milacic, Marija, 2026-03-09
nameRAC1, CDC42 activate NFκB
output[Complex:194047] NFKB1(1-433):RELA [nucleoplasm] [Homo sapiens]
regulatedBy[PositiveRegulation:9959029] Positive regulation by 'RAC1:GTP,(CDC42:GTP) [plasma membrane]'
releaseDate2026-03-25
reviewed[InstanceEdit:9975417] Raptis, Leda, 2025-11-21
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9958882] R-HSA-9958872.1
structureModified[InstanceEdit:9959037] Orlic-Milacic, Marija, 2025-06-26
summation[Summation:9958909]

Activation of RAC1 leads to an increase in the transcript...

(hasEvent)[Pathway:9958825] Activation of STAT3 by cadherin engagement [Homo sapiens]
(precedingEvent)[Reaction:9958869] Activated NFκB complex binds IL6 gene promoter [Homo sapiens]
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No pathways have been reviewed or authored by RAC1, CDC42 activate NFκB (9958872)