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Details on Person CASP4 cleaves IL1B at D27

Class:IdBlackBoxEvent:9958657
_displayNameCASP4 cleaves IL1B at D27
_doReleaseTRUE
_timestamp2025-08-18 13:53:16
authored[InstanceEdit:9947804] Shamovsky, Veronica, 2025-05-14
catalystActivity[CatalystActivity:9948006] cysteine-type endopeptidase activity of activated CASP4 [cytosol]
catalystActivityReference[CatalystActivityReference:9958784] cysteine-type endopeptidase activity of activated CASP4 [cytosol] The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases
compartment[Compartment:70101] cytosol
created[InstanceEdit:9958641] Shamovsky, Veronica, 2025-06-24
edited[InstanceEdit:9963520] Shamovsky, Veronica, 2025-08-14
input[EntityWithAccessionedSequence:448689] IL1B(1-269) [cytosol] [Homo sapiens]
internalReviewed[InstanceEdit:9960500] Matthews, Lisa, 2025-07-09
isChimericFALSE
literatureReference[LiteratureReference:9958631] The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases
modified[InstanceEdit:9958785] Shamovsky, Veronica, 2025-06-25
[InstanceEdit:9960494] Shamovsky, Veronica, 2025-07-14
[InstanceEdit:9960533] Shamovsky, Veronica, 2025-07-14
[InstanceEdit:9963536] Shamovsky, Veronica, 2025-08-14
[InstanceEdit:9963953] Shamovsky, Veronica, 2025-08-18
nameCASP4 cleaves IL1B at D27
output[EntityWithAccessionedSequence:9958616] IL1B(1-27) [cytosol] [Homo sapiens]
precedingEvent
releaseDate2025-09-18
reviewed[InstanceEdit:9963135] Shi, Xuyan, 2025-08-12
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9958669] R-HSA-9958657.1
summation[Summation:9958665] Caspase-4 (CASP4) cleaves pro–IL‑1β at D27, generating a p27...
(hasEvent)[Pathway:9960519] CASP4-mediated substrate cleavage [Homo sapiens]
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