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Details on Person For rotavirus A (RV-A) strains that reach late endosomes, su...
| Class:Id | Summation:9958419 |
|---|---|
| _displayName | For rotavirus A (RV-A) strains that reach late endosomes, su... |
| _timestamp | 2026-01-19 14:34:30 |
| created | [InstanceEdit:9958418] Orlic-Milacic, Marija, 2025-06-19 |
| modified | [InstanceEdit:9958446] Orlic-Milacic, Marija, 2025-06-20 [InstanceEdit:9958456] Orlic-Milacic, Marija, 2025-06-20 [InstanceEdit:9979425] Orlic-Milacic, Marija, 2026-01-19 |
| text | For rotavirus A (RV-A) strains that reach late endosomes, such as human RV-A strains Wa, WI61, and DS-1, and porcine strain YM, the exit from late endosomes to the cytosol, and thus infectivity in African green monkey kidney cell line MA104, requires cation-dependent mannose-6-phosphate receptor (M6PR) (Diaz-Salinas et al. 2014), as well as cation-independent mannose-6-phosphate receptor (IGF2R) (Diaz-Salinas et al. 2018). As M6PR and IGF2R are required for delivery of endosomal/lysosomal hydrolases, such as cathepsins, from the trans-Golgi network to the endosomes, and cathepsins B, L1 and S are required for infectivity in MA104 cells of the bovine RV-A strain UK (Diaz-Salinas et al. 2014) and infectivity in MA104 and human colon carcinoma cells Caco-2 of human RV-A strains Wa, WI61, and DS-1, and porcine strain YM (Diaz-Salinas et al. 2018), it is thought that M6PR and IGF2R deliver cathepsins to the late endosomes, which enable uncoating of RV-A triple layer particles (RV-A TLPs) to release RV-A double layer particles (RV-A DLPs) into the cytosol (Diaz-Salinas et al. 2014, Diaz-Salinas et al. 2018). RV-As whose DLPs are released into the cytosol from late endosomes are called late penetrating rotaviruses (Diaz-Salinas et al. 2014). |
| (summation) | [BlackBoxEvent:9954889] Release of RV-A DLP to cytosol from late endosome [Homo sapiens] |
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No pathways have been reviewed or authored by For rotavirus A (RV-A) strains that reach late endosomes, su... (9958419)
