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Both human rotavirus A (RV-A) strains Wa and DS-1, as wel...
| Class:Id | Summation:9957254 |
|---|---|
| _displayName | Both human rotavirus A (RV-A) strains Wa and DS-1, as wel... |
| _timestamp | 2026-01-19 16:23:07 |
| created | [InstanceEdit:9957253] Orlic-Milacic, Marija, 2025-06-17 |
| literatureReference | [LiteratureReference:9958097] Rotaviruses reach late endosomes and require the cation-dependent mannose-6-phosphate receptor and the activity of cathepsin proteases to enter the cell |
| modified | [InstanceEdit:9957256] Orlic-Milacic, Marija, 2025-06-17 [InstanceEdit:9957258] Orlic-Milacic, Marija, 2025-06-17 [InstanceEdit:9958101] Orlic-Milacic, Marija, 2025-06-19 [InstanceEdit:9958594] Orlic-Milacic, Marija, 2025-06-23 [InstanceEdit:9979425] Orlic-Milacic, Marija, 2026-01-19 [InstanceEdit:9979436] Orlic-Milacic, Marija, 2026-01-19 |
| text | Both human rotavirus A (RV-A) strains Wa and DS-1, as well as simian RRV strain of RV-A reach maturing endosomes during infection of the African green monkey kidney cell line MA104. A component of the ESCRT-II complex, VPS25, is required for the infectivity of all three strains in both MA104 cells and human colon carcinoma cell line Caco-2 (Silva-Ayala et al. 2013). A component of the ESCRT-III complex, VPS24, is required for the infectivity of RRV (its requirement was not tested for Wa and DS-1 strains), and the ESCRT-III-binding ATPase VPS4A is required for the infectivity of all three strains, co-localizing with RRV in endosomes likely corresponding to maturing endosomes in MA104 cells (Silva-Ayala et al. 2013). VPS4A is also required for infectivity of Caco-2 with RRV and DS-1, and its knockdown modestly impairs Wa infectivity (Silva-Ayala et al. 2013). VPS32 (CHMP4) component of the ESCRT-III complex is required for infection of Caco-2 cells with RRV and Wa strains, but not DS-1 strain (Silva-Ayala et al. 2013). The infectivity of the bovine UK strain of RV-A in MA104 cells is also dependent on VPS24 and VPS4A (Diaz-Salinas et al. 2014). |
| (summation) | [BlackBoxEvent:9954890] RV-A TLP transitions to mature endosome [Homo sapiens] |
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Both human rotavirus A (RV-A) strains Wa and DS-1, as wel... (9957254)
