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Details on Person CERT1-2 (ceramide transfer protein, isoform 2), an isoform o...

Class:IdSummation:9956912
_displayNameCERT1-2 (ceramide transfer protein, isoform 2), an isoform o...
_timestamp2025-06-16 19:33:09
created[InstanceEdit:9956913] D'Eustachio, Peter, 2025-06-16
modified[InstanceEdit:9956924] D'Eustachio, Peter, 2025-06-16
textCERT1-2 (ceramide transfer protein, isoform 2), an isoform of COL4A3BP, mediates the non-vesicular transfer of ceramide (CERA) from the endoplasmic reticulum (ER) membrane to the Golgi membrane at ER-Golgi membrane contact sites. This transfer is essential for cellular lipid homeostasis (Kumagai & Hanada 2019; Olayioye & Hausser 2012). CERT1-2 is associated with the cytosolic face of the ER membrane as part of a complex with PPM1L (protein phosphatase 1-like) (Saito et al. 2008) and VAPA or VAPB (VAMP-associated proteins A or B) (Kawano et al. 2006). The carboxyterminal START domain of CERT1-2 protein specifically binds ceramides (Hanada et al. 2003; Kudo et al. 2008). The PH domain of CERT1-2 can bridge the gap between the ER and the Golgi apparatus to transfer a CERA molecule extracted from the ER membrane to the Golgi (Hanada et al. 2003; Saito et al. 2008). CERT1-2-mediated ceramide transfer is positively regulated by OSBP (oxysterol binding protein), apparently through accumulation of phosphatidylinositol 4-phosphate (PI-4P) at membrane contact sites (Perry & Ridgway 2006; Goto et al. 2016).
(summation)[Reaction:9956909] CERT1-2 transfers CERA from the ER membrane to the Golgi membrane [Homo sapiens]
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