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Details on Person RV-A-activated CDC42 GEFs activate CDC42

Class:Id	Reaction:9956766
_displayName	RV-A-activated CDC42 GEFs activate CDC42
_doRelease	FALSE
_timestamp	2026-01-21 18:45:08
authored	[InstanceEdit:9979788] Orlic-Milacic, Marija, 2026-01-21
catalystActivity	[CatalystActivity:9956781] guanyl-nucleotide exchange factor activity of RV-A-activated CDC42 GEFs [cytosol]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9956775] Orlic-Milacic, Marija, 2025-06-13
disease	[Disease:3134794] viral infectious disease
input	[Complex:9013230] CDC42:GDP [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
isChimeric	FALSE
modified	[InstanceEdit:9962474] Orlic-Milacic, Marija, 2025-08-06 [InstanceEdit:9962931] Orlic-Milacic, Marija, 2025-08-12 [InstanceEdit:9979789] Orlic-Milacic, Marija, 2026-01-21 [InstanceEdit:9979800] Orlic-Milacic, Marija, 2026-01-21
name	RV-A-activated CDC42 GEFs activate CDC42
negativePrecedingEvent	[NegativePrecedingEvent:9979797] Futile Cycle: ARHGAP31 stimulates CDC42 GTPase activity
output	[Complex:182921] CDC42:GTP [plasma membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[BlackBoxEvent:9944133] RV-A virion attaches to an enterocyte [Homo sapiens] [BlackBoxEvent:9920465] Gut trypsin cleaves VP4 to yield VP5* and VP8* spike subunits [Homo sapiens]
regulatedBy	[PositiveRegulation:9956769] Positive regulation by 'RV-A TLP VP5:VP8 attached to host enterocyte [plasma membrane]'
relatedSpecies	[Species:9615053] Rotavirus A
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9956786] R-HSA-9956766.1
summation	[Summation:9956767] Attachment of the simian rotavirus A (RV-A) strain RRV to th...
(hasEvent)	[Pathway:9819336] Rotavirus A (RV-A) entry via receptor-mediated endocytosis [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9954891] Clathrin-dependent endocytosis of RV-A TLP [Homo sapiens] [BlackBoxEvent:9954894] Clathrin-independent endocytosis of RV-A TLP [Homo sapiens] [Reaction:9956768] ARHGAP31 stimulates CDC42 GTPase activity [Homo sapiens] [BlackBoxEvent:9958086] 26S proteasome-mediated degradation of PARD6B:aPKC in response to RV-A attachment [Homo sapiens]
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No pathways have been reviewed or authored by RV-A-activated CDC42 GEFs activate CDC42 (9956766)