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Details on Person OTC precursor is targeted to the mitochondrial matrix and processed

Class:IdBlackBoxEvent:9956502
_displayNameOTC precursor is targeted to the mitochondrial matrix and processed
_doReleaseTRUE
_timestamp2026-05-07 22:30:45
authored[InstanceEdit:9959888] Rothfels, Karen, 2025-07-02
compartment[Compartment:70101] cytosol
[Compartment:5460] mitochondrial matrix
created[InstanceEdit:9956504] Rothfels, Karen, 2025-06-12
edited[InstanceEdit:9959888] Rothfels, Karen, 2025-07-02
goBiologicalProcess[GO_BiologicalProcess:9988055] mitochondrial protein import pathway
input[EntityWithAccessionedSequence:9956408] OTC precursor [cytosol] [Homo sapiens]
internalReviewed[InstanceEdit:9960015] Orlic-Milacic, Marija, 2025-07-04
[InstanceEdit:9988070] D'Eustachio, Peter, 2026-05-01
[InstanceEdit:9988524] D'Eustachio, Peter, 2026-05-07
isChimericFALSE
literatureReference[LiteratureReference:71418] Structure and expression of a complementary DNA for the nuclear coded precursor of human mitochondrial ornithine transcarbamylase
[LiteratureReference:9609509] Mitochondrial Machineries for Protein Import and Assembly
[LiteratureReference:9956327] 1.85-A resolution crystal structure of human ornithine transcarbamoylase complexed with N-phosphonacetyl-L-ornithine. Catalytic mechanism and correlation with inherited deficiency
[LiteratureReference:9956330] Crystal structure of human ornithine transcarbamylase complexed with carbamoyl phosphate and L-norvaline at 1.9 A resolution
modified[InstanceEdit:9960130] Rothfels, Karen, 2025-07-07
[InstanceEdit:9970980] Rothfels, Karen, 2025-11-03
[InstanceEdit:9988059] D'Eustachio, Peter, 2026-05-01
[InstanceEdit:9988069] D'Eustachio, Peter, 2026-05-01
[InstanceEdit:9988428] D'Eustachio, Peter, 2026-05-07
[InstanceEdit:9988525] D'Eustachio, Peter, 2026-05-07
[InstanceEdit:9988528] D'Eustachio, Peter, 2026-05-07
nameOTC precursor is targeted to the mitochondrial matrix and processed
output[Complex:70558] OTC trimer [mitochondrial matrix] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
releaseDate2025-12-08
reviewed[InstanceEdit:9988529] Hill, David P, 2026-05-07
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9956505] R-HSA-9956502.1
summation[Summation:9956503] The gene encoding the mitochondrial enzyme ornithine transca...
(hasEvent)[Pathway:70635] Urea cycle [Homo sapiens]
(normalReaction)[FailedReaction:9956513] Leader sequence variants of OTC aren't targeted to the mitochondria [Homo sapiens]
(precedingEvent)[Reaction:70560] carbamoyl phosphate + ornithine => citrulline + orthophosphate [Homo sapiens]
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