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Details on Person SIRT5 desuccinylates CPS1

Class:IdReaction:9955518
_displayNameSIRT5 desuccinylates CPS1
_doReleaseTRUE
_timestamp2026-05-07 22:30:49
authored[InstanceEdit:9959888] Rothfels, Karen, 2025-07-02
catalystActivity[CatalystActivity:9955438] protein-succinyllysine desuccinylase activity of SIRT5 [mitochondrial matrix]
catalystActivityReference[CatalystActivityReference:9955502] protein-succinyllysine desuccinylase activity of SIRT5 [mitochondrial matrix] Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase
compartment[Compartment:5460] mitochondrial matrix
created[InstanceEdit:9955507] Rothfels, Karen, 2025-06-10
crossReference[DatabaseIdentifier:9955517] RHEA:47669
edited[InstanceEdit:9959888] Rothfels, Karen, 2025-07-02
inferredFrom
input[SimpleEntity:113526] NAD+ [mitochondrial matrix]
[SimpleEntity:113521] H2O [mitochondrial matrix]
[EntityWithAccessionedSequence:9955506] N6-succinyl K1291 CPS1 [mitochondrial matrix] [Homo sapiens]
internalReviewed[InstanceEdit:9960015] Orlic-Milacic, Marija, 2025-07-04
[InstanceEdit:9988070] D'Eustachio, Peter, 2026-05-01
[InstanceEdit:9988524] D'Eustachio, Peter, 2026-05-07
isChimericFALSE
literatureReference[LiteratureReference:9955100] Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase
[LiteratureReference:9955033] Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation
modified[InstanceEdit:9960130] Rothfels, Karen, 2025-07-07
[InstanceEdit:9970980] Rothfels, Karen, 2025-11-03
[InstanceEdit:9971326] Rothfels, Karen, 2025-11-05
[InstanceEdit:9988059] D'Eustachio, Peter, 2026-05-01
[InstanceEdit:9988069] D'Eustachio, Peter, 2026-05-01
[InstanceEdit:9988525] D'Eustachio, Peter, 2026-05-07
[InstanceEdit:9988528] D'Eustachio, Peter, 2026-05-07
nameSIRT5 desuccinylates CPS1
N(6)-succinyl-L-lysyl-(protein) + NAD(+) + H2O => 2''-O-succinyl-ADP-D-ribose + nicotinamide + L-lysyl-(protein)
output[SimpleEntity:5688274] NAM [mitochondrial matrix]
[SimpleEntity:9955509] 2''-O-succinyl-ADP-D-ribose(3-) [mitochondrial matrix]
[EntityWithAccessionedSequence:70544] CPS1 [mitochondrial matrix] [Homo sapiens]
previousReviewStatus[ReviewStatus:9821383] three stars
releaseDate2025-12-08
reviewed[InstanceEdit:9988529] Hill, David P, 2026-05-07
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9955520] R-HSA-9955518.1
summation[Summation:9955508] Based on studies in mouse, SIRT5 removes succinyl groups fro...
(hasEvent)[Pathway:70635] Urea cycle [Homo sapiens]
(precedingEvent)[Reaction:70555] 2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] [Homo sapiens]
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No pathways have been reviewed or authored by SIRT5 desuccinylates CPS1 (9955518)
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