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The rotavirus A (RV-A) strains Wa (human), TFR-41 (porcin...
| Class:Id | Summation:9955312 |
|---|---|
| _displayName | The rotavirus A (RV-A) strains Wa (human), TFR-41 (porcin... |
| _timestamp | 2025-06-23 19:15:28 |
| created | [InstanceEdit:9955313] Orlic-Milacic, Marija, 2025-06-10 |
| literatureReference | [LiteratureReference:9920448] The spike protein VP4 defines the endocytic pathway used by rotavirus to enter MA104 cells [LiteratureReference:9954935] Different rotavirus strains enter MA104 cells through different endocytic pathways: the role of clathrin-mediated endocytosis [LiteratureReference:9955832] Ultrastructural evidence for the cellular uptake of rotavirus by endocytosis [LiteratureReference:9958097] Rotaviruses reach late endosomes and require the cation-dependent mannose-6-phosphate receptor and the activity of cathepsin proteases to enter the cell |
| modified | [InstanceEdit:9955835] Orlic-Milacic, Marija, 2025-06-11 [InstanceEdit:9956578] Orlic-Milacic, Marija, 2025-06-13 [InstanceEdit:9958101] Orlic-Milacic, Marija, 2025-06-19 [InstanceEdit:9958594] Orlic-Milacic, Marija, 2025-06-23 |
| text | The rotavirus A (RV-A) strains Wa (human), TFR-41 (porcine), and UK (bovine), share the requirements for HSPA8 (HSC70), DNM2 (dynamin), and cholesterol with the simian RRV strain, but contrary to RRV, they enter the host cells (African green monkey kidney cell line MA104 was used) through clathrin-mediated endocytosis, since treatments that inhibit clathrin-mediated endocytosis, such as pre-treatment of cells with hypertonic medium or RNAi-mediated knockdown of clathrin heavy chain (CLTC) significantly reduce their infectivity (Gutierrez et al. 2010). Experiments with the reassortant bovine UK and simian RRV viruses have shown that the spike protein VP4 genotype defines the endocytic pathway used by the RV-A to enter MA104 cells, and confirmed the entry of the human strain Wa, as well as human RV-A strains WI-61 and DS-1 through clathrin-mediated endocytosis (Diaz-Salinas et al. 2013). The first findings suggestive of clathrin-mediated endocytosis of RV-A came from the ultrastructural studies, where it was observed that the simian SA11 strain entered MA104 cells through coated pits and coated vesicles (Quan and Doane 1983). The entry of the RV-A bovine UK strain is positively regulated by CDC42 RHO GTPase (Diaz-Salinas et al. 2014). |
| (summation) | [BlackBoxEvent:9954891] Clathrin-dependent endocytosis of RV-A TLP [Homo sapiens] |
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The rotavirus A (RV-A) strains Wa (human), TFR-41 (porcin... (9955312)
