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Details on Person To subvert the host immune response, the Gram-negative bacte...

Class:IdSummation:9955168
_displayNameTo subvert the host immune response, the Gram-negative bacte...
_timestamp2025-06-10 04:27:43
created[InstanceEdit:9955206] Shamovsky, Veronica, 2025-06-10
literatureReference[LiteratureReference:9955177] Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence
[LiteratureReference:9955178] GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8
[LiteratureReference:9947850] Structural mechanism for guanylate-binding proteins (GBPs) targeting by the Shigella E3 ligase IpaH9.8
[LiteratureReference:9955140] Substrate-binding destabilizes the hydrophobic cluster to relieve the autoinhibition of bacterial ubiquitin ligase IpaH9.8
[LiteratureReference:9955145] Shigella IpaH9.8 limits GBP1-dependent LPS release from intracytosolic bacteria to suppress caspase-4 activation
[LiteratureReference:9955189] Convergent evolution in the assembly of polyubiquitin degradation signals by the Shigella flexneri IpaH9.8 ligase
[LiteratureReference:9955205] Type III secretion effectors of the IpaH family are E3 ubiquitin ligases
textTo subvert the host immune response, the Gram-negative bacterium Shigella flexneri delivers its effector protein IpaH9.8 into host cells via the type III secretion system. Once inside the host cytosol, IpaH9.8 functions as an E3 ubiquitin ligase, recruiting host E2 ubiquitin-conjugating enzymes and catalyzing the attachment of K48-linked polyubiquitin chains to target proteins (Rohde JR et al., 2007; Edwards DJ et al., 2014). Among the substrates of IpaH9.8 are guanylate-binding proteins (GBPs), including GBP1, GBP2, GBP4, and GBP6. The K48-linked polyubiquitin chains mark GBPs for recognition and degradation by the 26S proteasome, thereby abrogating their antimicrobial functions. GBP3 and GBP7 are not targeted by ipaH9.8 for ubiquitination (Wandel MP et al., 2017; Li P et al., 2017; Ji C et al. 2019; Ye Y et al., 2020; Goers L et al., 2023).
(summation)[BlackBoxEvent:9955146] S.flexneri ipaH9.8 ubiquitinates GBPs [Homo sapiens]
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