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Details on Person ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released

Class:Id	Reaction:9954919
_displayName	ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released
_doRelease	TRUE
_timestamp	2025-11-07 01:18:07
authored	[InstanceEdit:9954885] May, Bruce, 2025-06-09
catalystActivity	[CatalystActivity:9955744] GTPase activity of PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9954909] May, Bruce, 2025-06-09
edited	[InstanceEdit:9954885] May, Bruce, 2025-06-09
input	[Complex:9954724] PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide [cytosol] [Homo sapiens] [Complex:9955878] ABCE1:ATP [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9960460] Matthews, Lisa, 2025-07-13
isChimeric	FALSE
literatureReference	[LiteratureReference:9955732] Structural basis of highly conserved ribosome recycling in eukaryotes and archaea
modified	[InstanceEdit:9955739] May, Bruce, 2025-06-11 [InstanceEdit:9955751] May, Bruce, 2025-06-11 [InstanceEdit:9955884] May, Bruce, 2025-06-12 [InstanceEdit:9960462] May, Bruce, 2025-07-13 [InstanceEdit:9962797] May, Bruce, 2025-08-09 [InstanceEdit:9971549] May, Bruce, 2025-11-07
name	ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released
output	[Complex:9954910] ABCE1:ATP:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] [Homo sapiens] [Complex:9955745] HBS1L-1:GDP [cytosol] [Homo sapiens] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:9954730] PELO:HBS1L-1:GTP binds 80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-09-18
reviewed	[InstanceEdit:9962796] Bennett, Eric J, 2025-08-09 [InstanceEdit:9962794] Ford, Pierce W, 2025-08-09 [InstanceEdit:9971505] Jafarnejad, Seyed Mehdi, 2025-11-07 [InstanceEdit:9971510] McGirr, Tom, 2025-11-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9954920] R-HSA-9954919.2
structureModified	[InstanceEdit:9955751] May, Bruce, 2025-06-11 [InstanceEdit:9955884] May, Bruce, 2025-06-12
summation	[Summation:9954914] HBS1L, a paralog of eRF3, hydrolyzes GTP, causing HBS1L:GDP ...
(hasEvent)	[Pathway:9954714] PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9955731] ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide [Homo sapiens]
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No pathways have been reviewed or authored by ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released (9954919)