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Details on Person Clathrin-dependent endocytosis of RV-A TLP

Class:Id	BlackBoxEvent:9954891
_displayName	Clathrin-dependent endocytosis of RV-A TLP
_doRelease	FALSE
_timestamp	2026-01-21 18:43:58
authored	[InstanceEdit:9979788] Orlic-Milacic, Marija, 2026-01-21
created	[InstanceEdit:9954892] Orlic-Milacic, Marija, 2025-06-09
disease	[Disease:3134794] viral infectious disease
input	[Complex:9954538] RV-A TLP VP5:VP8 attached to host enterocyte [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9954935] Different rotavirus strains enter MA104 cells through different endocytic pathways: the role of clathrin-mediated endocytosis [LiteratureReference:9920448] The spike protein VP4 defines the endocytic pathway used by rotavirus to enter MA104 cells
modified	[InstanceEdit:9954907] Orlic-Milacic, Marija, 2025-06-09 [InstanceEdit:9955273] Orlic-Milacic, Marija, 2025-06-10 [InstanceEdit:9955314] Orlic-Milacic, Marija, 2025-06-10 [InstanceEdit:9955315] Orlic-Milacic, Marija, 2025-06-10 [InstanceEdit:9956578] Orlic-Milacic, Marija, 2025-06-13 [InstanceEdit:9958101] Orlic-Milacic, Marija, 2025-06-19 [InstanceEdit:9962474] Orlic-Milacic, Marija, 2025-08-06 [InstanceEdit:9962931] Orlic-Milacic, Marija, 2025-08-12 [InstanceEdit:9979789] Orlic-Milacic, Marija, 2026-01-21 [InstanceEdit:9979800] Orlic-Milacic, Marija, 2026-01-21
name	Clathrin-dependent endocytosis of RV-A TLP
output	[Complex:9955264] RV-A TLP VP5:VP8 [clathrin-coated endocytic vesicle] [Rotavirus A]
precedingEvent	[BlackBoxEvent:9944133] RV-A virion attaches to an enterocyte [Homo sapiens] [BlackBoxEvent:9920465] Gut trypsin cleaves VP4 to yield VP5* and VP8* spike subunits [Homo sapiens] [Reaction:9956766] RV-A-activated CDC42 GEFs activate CDC42 [Homo sapiens] [BlackBoxEvent:9944133] RV-A virion attaches to an enterocyte [Homo sapiens]
regulatedBy	[PositiveRegulation:9934676] Positive regulation by 'DNM2 [plasma membrane]' [PositiveRegulation:9955135] Positive regulation by 'HSPA8 [plasma membrane]' [PositiveRegulation:9955136] Positive regulation by 'cholesterol [plasma membrane]' [Requirement:189132] Requirement by 'Clathrin [plasma membrane]' [PositiveRegulation:9956772] Positive regulation by 'CDC42:GTP [plasma membrane]'
relatedSpecies	[Species:9615053] Rotavirus A
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9954902] R-HSA-9954891.1
structureModified	[InstanceEdit:9954907] Orlic-Milacic, Marija, 2025-06-09 [InstanceEdit:9955273] Orlic-Milacic, Marija, 2025-06-10 [InstanceEdit:9955315] Orlic-Milacic, Marija, 2025-06-10 [InstanceEdit:9958101] Orlic-Milacic, Marija, 2025-06-19
summation	[Summation:9955312] The rotavirus A (RV-A) strains Wa (human), TFR-41 (porcin...
(hasEvent)	[Pathway:9819336] Rotavirus A (RV-A) entry via receptor-mediated endocytosis [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9954896] RV-A TLP transitions from clathrin-coated endocytic vesicle to early endosome [Homo sapiens]
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