Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person May, Bruce, 2025-06-08

Class:IdInstanceEdit:9954763
_displayNameMay, Bruce, 2025-06-08
_timestamp2025-06-08 14:03:00
author[Person:203835] May, Bruce
dateTime2025-06-08 14:02:50
(modified)[GenomeEncodedEntity:9948289] non-stop mRNA [cytosol] [Homo sapiens]
[Reaction:9948291] RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide [Homo sapiens]
[Complex:9948295] RQT complex:K63polyUb-80S Ribosome:no-go mRNA:peptidyl tRNA with nascent peptide [cytosol] [Homo sapiens]
[Pathway:9948299] Ribosome-associated quality control [Homo sapiens]
[Reaction:9948300] RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide [Homo sapiens]
[Complex:9948304] NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala [cytosol] [Homo sapiens]
[Complex:9948313] ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol] [Homo sapiens]
[Reaction:9948317] ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome [Homo sapiens]
[Reaction:9948318] LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala [Homo sapiens]
[Complex:9948321] K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] [Homo sapiens]
List all 27 refering instances
(structureModified)[Pathway:9948299] Ribosome-associated quality control [Homo sapiens]
[Reaction:9948300] RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide [Homo sapiens]
[Reaction:9948317] ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome [Homo sapiens]
[Reaction:9948318] LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala [Homo sapiens]
[Reaction:9948458] NEMF polymerizes alanine residues onto the C-terminus of the nascent peptide ("CAT tailing") [Homo sapiens]
[BlackBoxEvent:9949676] The proteasome degrades the alanine-tailed K48-polyUb nascent peptide bound to LTN1:NEMF:TCF25:VCP hexamer [Homo sapiens]
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No pathways have been reviewed or authored by May, Bruce, 2025-06-08 (9954763)