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Details on Person NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide

Class:Id	Reaction:9954721
_displayName	NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide
_doRelease	TRUE
_timestamp	2025-11-07 01:21:32
authored	[InstanceEdit:9954726] May, Bruce, 2025-06-06
catalystActivity	[CatalystActivity:9960454] ubiquitin-protein transferase activity of NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10:nascent peptide-Alanine [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9954738] May, Bruce, 2025-06-08
edited	[InstanceEdit:9954726] May, Bruce, 2025-06-06
input	[Complex:9954711] NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10:nascent peptide-Alanine [cytosol] [Homo sapiens] [Complex:8939330] Ub:UBE2D2 [cytosol] [Homo sapiens] [Complex:8939330] Ub:UBE2D2 [cytosol] [Homo sapiens] [Complex:8939330] Ub:UBE2D2 [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9960460] Matthews, Lisa, 2025-07-13
isChimeric	FALSE
literatureReference	[LiteratureReference:9949737] Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing
modified	[InstanceEdit:9954836] May, Bruce, 2025-06-09 [InstanceEdit:9954861] May, Bruce, 2025-06-09 [InstanceEdit:9955884] May, Bruce, 2025-06-12 [InstanceEdit:9960458] May, Bruce, 2025-07-12 [InstanceEdit:9960462] May, Bruce, 2025-07-13 [InstanceEdit:9962797] May, Bruce, 2025-08-09 [InstanceEdit:9971549] May, Bruce, 2025-11-07
name	NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide
output	[EntityWithAccessionedSequence:934628] UBE2D2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:934628] UBE2D2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:934628] UBE2D2 [cytosol] [Homo sapiens] [Complex:9954717] NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 [cytosol] [Homo sapiens] [Complex:9948421] K48polyUb-nascent peptide-Alanine [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9954723] NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 binds alanine-tailed nascent peptide [Homo sapiens] [Reaction:9948458] NEMF polymerizes alanine residues onto the C-terminus of the nascent peptide ("CAT tailing") [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-09-18
reviewed	[InstanceEdit:9962796] Bennett, Eric J, 2025-08-09 [InstanceEdit:9962794] Ford, Pierce W, 2025-08-09 [InstanceEdit:9971505] Jafarnejad, Seyed Mehdi, 2025-11-07 [InstanceEdit:9971510] McGirr, Tom, 2025-11-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9954744] R-HSA-9954721.2
structureModified	[InstanceEdit:9960458] May, Bruce, 2025-07-12
summation	[Summation:9954859] The CRL-KLHDC10 E3 ubiquitin ligase complex (NEDD8-K699-CUL2...
(hasEvent)	[Pathway:9954709] Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9954728] The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide [Homo sapiens]
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No pathways have been reviewed or authored by NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide (9954721)