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Details on Person PKG phosphorylates NS5

Class:IdReaction:9954423
_displayNamePKG phosphorylates NS5
_doReleaseTRUE
_timestamp2025-10-30 11:55:14
authored[InstanceEdit:9954391] Stephan, Ralf, 2025-06-04
catalystActivity[CatalystActivity:427882] cGMP-dependent protein kinase activity of cGMP-dependent protein kinase 1, alpha isozyme [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9954417] Stephan, Ralf, 2025-06-07
crossReference[DatabaseIdentifier:9857129] RHEA:46609
disease[Disease:3244610] dengue disease
edited[InstanceEdit:9970471] Stephan, Ralf, 2025-10-30
input[EntityWithAccessionedSequence:9918834] pre-NS5 [endoplasmic reticulum membrane] [Dengue virus type 2]
[SimpleEntity:113592] ATP [cytosol]
internalReviewed[InstanceEdit:9925762] Orlic-Milacic, Marija, 2024-10-23
[InstanceEdit:9959999] Matthews, Lisa, 2025-07-04
isChimericFALSE
literatureReference[LiteratureReference:9920119] Protein kinase G phosphorylates mosquito-borne flavivirus NS5
[LiteratureReference:9920023] Association between NS3 and NS5 proteins of dengue virus type 2 in the putative RNA replicase is linked to differential phosphorylation of NS5
modified[InstanceEdit:9960001] Stephan, Ralf, 2025-07-04
[InstanceEdit:9960002] Stephan, Ralf, 2025-07-04
[InstanceEdit:9963605] Stephan, Ralf, 2025-08-15
[InstanceEdit:9964208] Stephan, Ralf, 2025-08-20
[InstanceEdit:9966338] Stephan, Ralf, 2025-09-19
[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
namePKG phosphorylates NS5
output[EntityWithAccessionedSequence:9919971] p-NS5 [endoplasmic reticulum membrane] [Dengue virus type 2]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:70106] H+ [cytosol]
previousReviewStatus[ReviewStatus:9821383] three stars
relatedSpecies[Species:3244621] Dengue virus type 2
releaseDate2025-12-08
reviewed[InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29
[InstanceEdit:9970204] Mansur, Daniel Santos, 2025-10-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48898] Bos taurus
stableIdentifier[StableIdentifier:9954482] R-BTA-9954423.1
summation[Summation:9920113] NS5 from DENV-2 (strain U87411) is phosphorylated at Thr-449...
(inferredFrom)[Reaction:9920025] PKG phosphorylates NS5 [Homo sapiens]
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No pathways have been reviewed or authored by PKG phosphorylates NS5 (9954423)