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Details on Person PIM1 phosphorylates GBP1

Class:IdReaction:9954237
_displayNamePIM1 phosphorylates GBP1
_doReleaseTRUE
_timestamp2025-11-06 22:41:00
authored[InstanceEdit:9963520] Shamovsky, Veronica, 2025-08-14
catalystActivity[CatalystActivity:9954235] protein serine/threonine kinase activity of PIM1 [cytosol]
catalystActivityReference[CatalystActivityReference:9954262] protein serine/threonine kinase activity of PIM1 [cytosol] PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection
compartment[Compartment:70101] cytosol
created[InstanceEdit:9954263] Shamovsky, Veronica, 2025-06-06
edited[InstanceEdit:9970963] Shamovsky, Veronica, 2025-11-03
goBiologicalProcess[GO_BiologicalProcess:2267015] negative regulation of defense response to bacterium
input[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[EntityWithAccessionedSequence:9947912] S-farn-C589-GBP1 [cytosol] [Homo sapiens]
internalReviewed[InstanceEdit:9968331] Matthews, Lisa, 2025-10-13
isChimericFALSE
literatureReference[LiteratureReference:9954264] PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection
modified[InstanceEdit:9968562] Shamovsky, Veronica, 2025-10-16
[InstanceEdit:9970623] Shamovsky, Veronica, 2025-10-31
[InstanceEdit:9970967] Shamovsky, Veronica, 2025-11-03
[InstanceEdit:9971501] Shamovsky, Veronica, 2025-11-06
namePIM1 phosphorylates GBP1
output[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[EntityWithAccessionedSequence:9954274] S-farn-C589, p-S156, T590-GBP1 [cytosol] [Homo sapiens]
regulatedBy[NegativeRegulation:9968564] Negative regulation by 'S-farn-GBP1:GTP [cytosol]'
regulationReference[RegulationReference:9968563] Negative regulation by 'S-farn-GBP1:GTP [cytosol]' GTP is an allosteric modulator of the interaction between the guanylate-binding protein 1 and the prosurvival kinase PIM1
releaseDate2025-12-08
reviewed[InstanceEdit:9970618] Daumke, Oliver, 2025-10-31
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9954284] R-HSA-9954237.1
structureModified[InstanceEdit:9968562] Shamovsky, Veronica, 2025-10-16
summation[Summation:9954258] Proto-oncogene serine/threonine kinase 1 (PIM1) phosphorylat...
(hasEvent)[Pathway:9968551] Regulation of GBP-mediated host defense [Homo sapiens]
(precedingEvent)[Reaction:9954260] SFN binds S-farn-C589,p-S156,T590-GBP1 [Homo sapiens]
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