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Details on Person GMP dissociates from the GBP1 oligomer

Class:Id	Reaction:9953173
_displayName	GMP dissociates from the GBP1 oligomer
_doRelease	TRUE
_timestamp	2025-11-06 22:40:54
authored	[InstanceEdit:9963520] Shamovsky, Veronica, 2025-08-14
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9953154] Shamovsky, Veronica, 2025-05-28
edited	[InstanceEdit:9970963] Shamovsky, Veronica, 2025-11-03
input	[Complex:9947870] GBP1 oligomer:GMP:LPS [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9968331] Matthews, Lisa, 2025-10-13
isChimeric	FALSE
literatureReference	[LiteratureReference:9947890] Structural insights into the activation mechanism of antimicrobial GBP1 [LiteratureReference:9947931] How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP [LiteratureReference:9953136] Insight into temperature dependence of GTPase activity in human guanylate binding protein-1 [LiteratureReference:9953147] Transient kinetic investigation of GTP hydrolysis catalyzed by interferon-gamma-induced hGBP1 (human guanylate binding protein 1)
modified	[InstanceEdit:9959651] Shamovsky, Veronica, 2025-07-01 [InstanceEdit:9968562] Shamovsky, Veronica, 2025-10-16 [InstanceEdit:9970623] Shamovsky, Veronica, 2025-10-31 [InstanceEdit:9970965] Shamovsky, Veronica, 2025-11-03 [InstanceEdit:9971501] Shamovsky, Veronica, 2025-11-06
name	GMP dissociates from the GBP1 oligomer
output	[SimpleEntity:113578] GMP [cytosol] [SimpleEntity:6803081] LPS [peptidoglycan-based cell wall] [EntityWithAccessionedSequence:9947912] S-farn-C589-GBP1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9947887] GBP1 hydrolyzes GDP [Homo sapiens] [Polymerisation:9947842] GBP1 hydrolyzes GTP forming GBP1 oligomers [Homo sapiens]
releaseDate	2025-12-08
reviewed	[InstanceEdit:9970618] Daumke, Oliver, 2025-10-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9953178] R-HSA-9953173.1
structureModified	[InstanceEdit:9959651] Shamovsky, Veronica, 2025-07-01
summation	[Summation:9953166] Guanylate-binding protein 1 (GBP1) mediates a two-step hydro...
(hasEvent)	[Pathway:9953170] GBP-mediated host defense [Homo sapiens]
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No pathways have been reviewed or authored by GMP dissociates from the GBP1 oligomer (9953173)