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Details on Person The proteasome degrades the K48-polyUb nascent peptide-Ala-Thr bound to RKR1:RQC2:RQC1:CDC48 hexamer

Class:Id	BlackBoxEvent:9953094
_displayName	The proteasome degrades the K48-polyUb nascent peptide-Ala-Thr bound to RKR1:RQC2:RQC1:CDC48 hexamer
_doRelease	TRUE
_timestamp	2025-08-11 12:57:58
authored	[InstanceEdit:9953093] May, Bruce, 2025-05-28
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9953092] May, Bruce, 2025-05-28
edited	[InstanceEdit:9953093] May, Bruce, 2025-05-28
input	[Complex:9950040] RKR1:RQC2:RQC1:CDC48 hexamer:K48polyUb-nascent peptide-Ala-Thr [cytosol] [Saccharomyces cerevisiae]
internalReviewed	[InstanceEdit:9960460] Matthews, Lisa, 2025-07-13
isChimeric	FALSE
literatureReference	[LiteratureReference:9950596] The ribosome-bound quality control complex remains associated to aberrant peptides during their proteasomal targeting and interacts with Tom1 to limit protein aggregation [LiteratureReference:9953182] The Cdc48 unfoldase prepares well-folded protein substrates for degradation by the 26S proteasome
modified	[InstanceEdit:9953183] May, Bruce, 2025-05-28 [InstanceEdit:9954763] May, Bruce, 2025-06-08 [InstanceEdit:9955884] May, Bruce, 2025-06-12 [InstanceEdit:9960462] May, Bruce, 2025-07-13 [InstanceEdit:9962797] May, Bruce, 2025-08-09 [InstanceEdit:9962846] May, Bruce, 2025-08-11
name	The proteasome degrades the K48-polyUb nascent peptide-Ala-Thr bound to RKR1:RQC2:RQC1:CDC48 hexamer
output	[EntityWithAccessionedSequence:9950048] RKR1 [cytosol] [Saccharomyces cerevisiae] [EntityWithAccessionedSequence:9950013] RQC1 [cytosol] [Saccharomyces cerevisiae] [EntityWithAccessionedSequence:9950031] RQC2 [cytosol] [Saccharomyces cerevisiae] [Complex:9950027] CDC48 hexamer [cytosol] [Saccharomyces cerevisiae]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-09-18
reviewed	[InstanceEdit:9962796] Bennett, Eric J, 2025-08-09 [InstanceEdit:9962794] Ford, Pierce W, 2025-08-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:68322] Saccharomyces cerevisiae
stableIdentifier	[StableIdentifier:9953095] R-SCE-9953094.1
summation	[Summation:9953091] CDC48 unfolds proteins to provide unstructured regions that ...
(inferredFrom)	[BlackBoxEvent:9949676] The proteasome degrades the alanine-tailed K48-polyUb nascent peptide bound to LTN1:NEMF:TCF25:VCP hexamer [Homo sapiens]
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No pathways have been reviewed or authored by The proteasome degrades the K48-polyUb nascent peptide-Ala-Thr bound to RKR1:RQC2:RQC1:CDC48 hexamer (9953094)