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Details on Person The proteasome degrades the alanine-tailed K48-polyUb nascent peptide bound to LTN1:NEMF:TCF25:VCP hexamer

Class:Id	BlackBoxEvent:9949676
_displayName	The proteasome degrades the alanine-tailed K48-polyUb nascent peptide bound to LTN1:NEMF:TCF25:VCP hexamer
_doRelease	TRUE
_timestamp	2025-11-07 01:26:49
authored	[InstanceEdit:9949682] May, Bruce, 2025-05-24
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9949679] May, Bruce, 2025-05-24
edited	[InstanceEdit:9949682] May, Bruce, 2025-05-24
inferredFrom	[BlackBoxEvent:9953094] The proteasome degrades the K48-polyUb nascent peptide-Ala-Thr bound to RKR1:RQC2:RQC1:CDC48 hexamer [Saccharomyces cerevisiae]
input	[Complex:9949672] LTN1:NEMF:TCF25:VCP hexamer:K48polyUb-nascent peptide-Ala [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9960460] Matthews, Lisa, 2025-07-13
isChimeric	FALSE
modified	[InstanceEdit:9953096] May, Bruce, 2025-05-28 [InstanceEdit:9953183] May, Bruce, 2025-05-28 [InstanceEdit:9954763] May, Bruce, 2025-06-08 [InstanceEdit:9955884] May, Bruce, 2025-06-12 [InstanceEdit:9960462] May, Bruce, 2025-07-13 [InstanceEdit:9962797] May, Bruce, 2025-08-09 [InstanceEdit:9971549] May, Bruce, 2025-11-07
name	The proteasome degrades the alanine-tailed K48-polyUb nascent peptide bound to LTN1:NEMF:TCF25:VCP hexamer
output	[EntityWithAccessionedSequence:5688967] LTN1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9948358] NEMF [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9948400] TCF25 [cytosol] [Homo sapiens] [Complex:5362364] VCP hexamer [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9949632] VCP hexamer extracts K48 polyubiquitinated alanine-tailed nascent peptide from VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:K48polyUb-nascent peptide [Homo sapiens] [Reaction:9948427] ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-09-18
reviewed	[InstanceEdit:9962796] Bennett, Eric J, 2025-08-09 [InstanceEdit:9962794] Ford, Pierce W, 2025-08-09 [InstanceEdit:9971505] Jafarnejad, Seyed Mehdi, 2025-11-07 [InstanceEdit:9971510] McGirr, Tom, 2025-11-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9949688] R-HSA-9949676.2
structureModified	[InstanceEdit:9954763] May, Bruce, 2025-06-08
summation	[Summation:9953090] VCP unfolds proteins to provide unstructured regions that ca...
(hasEvent)	[Pathway:9954709] Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide [Homo sapiens]
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No pathways have been reviewed or authored by The proteasome degrades the alanine-tailed K48-polyUb nascent peptide bound to LTN1:NEMF:TCF25:VCP hexamer (9949676)