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Details on Person miR-449 and miR-34 repress NOTCH1 mRNA translation

Class:Id	BlackBoxEvent:9949534
_displayName	miR-449 and miR-34 repress NOTCH1 mRNA translation
_doRelease	TRUE
_timestamp	2026-05-08 19:13:59
authored	[InstanceEdit:9962119] Rothfels, Karen, 2025-07-31
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9949543] Rothfels, Karen, 2025-05-22
edited	[InstanceEdit:9962258] Rothfels, Karen, 2025-07-31
input	[EntityWithAccessionedSequence:1606559] NOTCH1 mRNA [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9962310] Orlic-Milacic, Marija, 2025-08-03
isChimeric	FALSE
literatureReference	[LiteratureReference:1606696] MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells [LiteratureReference:1606546] Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway [LiteratureReference:9960280] MicroRNA-based silencing of Delta/Notch signaling promotes multiple cilia formation [LiteratureReference:9960267] Fine-tuning multiciliated cell differentiation at the post-transcriptional level: contribution of miR-34/449 family members [LiteratureReference:9949507] Control of multiciliogenesis by miR-34/449 in the male reproductive tract through enforcing cell cycle exit [LiteratureReference:9960289] miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110 [LiteratureReference:9960286] Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis
modified	[InstanceEdit:9960320] Rothfels, Karen, 2025-07-09 [InstanceEdit:9962260] Rothfels, Karen, 2025-08-01 [InstanceEdit:9962309] Rothfels, Karen, 2025-08-03 [InstanceEdit:9962312] Rothfels, Karen, 2025-08-03 [InstanceEdit:9988567] Rothfels, Karen, 2026-05-08 [InstanceEdit:9988586] Rothfels, Karen, 2026-05-08 [InstanceEdit:9988643] Rothfels, Karen, 2026-05-08
name	miR-449 and miR-34 repress NOTCH1 mRNA translation
output	[Complex:157027] NOTCH1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1606682] MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA [Homo sapiens] [BlackBoxEvent:1912416] NOTCH1 gene transcription [Homo sapiens] [BlackBoxEvent:1912406] p53 positively regulates transcription of MIR34 microRNAs [Homo sapiens] [Reaction:1606561] MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA [Homo sapiens] [BlackBoxEvent:1912416] NOTCH1 gene transcription [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:9949537] Negative gene expression regulation by 'NOTCH1 mRNA:miR-449 RISC [cytosol]' [NegativeGeneExpressionRegulation:9949539] Negative gene expression regulation by 'NOTCH1 mRNA:miR-34 RISC [cytosol]'
regulationReference	[RegulationReference:9949542] Negative gene expression regulation by 'NOTCH1 mRNA:miR-34 RISC [cytosol]' Control of multiciliogenesis by miR-34/449 in the male reproductive tract through enforcing cell cycle exit [RegulationReference:9949535] Negative gene expression regulation by 'NOTCH1 mRNA:miR-449 RISC [cytosol]' Control of multiciliogenesis by miR-34/449 in the male reproductive tract through enforcing cell cycle exit
releaseDate	2026-06-17
reviewed	[InstanceEdit:9988641] Dutcher, Susan K, 2026-05-08 [InstanceEdit:9988584] Rayamajhi, Dheeraj, 2026-05-08 [InstanceEdit:9988583] Roy, Sudipto, 2026-05-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9949546] R-HSA-9949534.1
summation	[Summation:9949532] Translation of NOTCH1 mRNA is negatively regulated by miR-34...
(hasEvent)	[Pathway:9945556] Transcriptional regulation of multiciliogenesis [Homo sapiens]
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No pathways have been reviewed or authored by miR-449 and miR-34 repress NOTCH1 mRNA translation (9949534)