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Details on Person mir-34 RISC binds DLL1 mRNA

Class:Id	Reaction:9949530
_displayName	mir-34 RISC binds DLL1 mRNA
_doRelease	TRUE
_timestamp	2026-05-08 19:14:01
authored	[InstanceEdit:9962119] Rothfels, Karen, 2025-07-31
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9949543] Rothfels, Karen, 2025-05-22
edited	[InstanceEdit:9962258] Rothfels, Karen, 2025-07-31
input	[DefinedSet:1606685] miR-34 RISC [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9949522] DLL1 mRNA [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9962310] Orlic-Milacic, Marija, 2025-08-03
isChimeric	FALSE
literatureReference	[LiteratureReference:1606546] Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway [LiteratureReference:9960267] Fine-tuning multiciliated cell differentiation at the post-transcriptional level: contribution of miR-34/449 family members [LiteratureReference:9988562] miR-34b regulates multiciliogenesis during organ formation in zebrafish [LiteratureReference:9949507] Control of multiciliogenesis by miR-34/449 in the male reproductive tract through enforcing cell cycle exit [LiteratureReference:9960280] MicroRNA-based silencing of Delta/Notch signaling promotes multiple cilia formation [LiteratureReference:9960289] miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110 [LiteratureReference:9960286] Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis
modified	[InstanceEdit:9960319] Rothfels, Karen, 2025-07-09 [InstanceEdit:9962260] Rothfels, Karen, 2025-08-01 [InstanceEdit:9962312] Rothfels, Karen, 2025-08-03 [InstanceEdit:9988566] Rothfels, Karen, 2026-05-08 [InstanceEdit:9988586] Rothfels, Karen, 2026-05-08 [InstanceEdit:9988643] Rothfels, Karen, 2026-05-08
name	mir-34 RISC binds DLL1 mRNA
output	[Complex:9949525] DLL1 mRNA:miR-34 RISC [cytosol] [Homo sapiens]
releaseDate	2026-06-17
reviewed	[InstanceEdit:9988641] Dutcher, Susan K, 2026-05-08 [InstanceEdit:9988584] Rayamajhi, Dheeraj, 2026-05-08 [InstanceEdit:9988583] Roy, Sudipto, 2026-05-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9949547] R-HSA-9949530.1
summation	[Summation:9960310] Translation of DLL1 mRNA is negatively regulated by MIR34 mi...
(hasEvent)	[Pathway:9945556] Transcriptional regulation of multiciliogenesis [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9949538] miR-449 and miR-34 repress DLL1 mRNA translation [Homo sapiens]
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No pathways have been reviewed or authored by mir-34 RISC binds DLL1 mRNA (9949530)