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Details on Person NEMF polymerizes alanine residues onto the C-terminus of the nascent peptide ("CAT tailing")

Class:IdReaction:9948458
_displayNameNEMF polymerizes alanine residues onto the C-terminus of the nascent peptide ("CAT tailing")
_doReleaseTRUE
_timestamp2025-11-07 01:22:41
authored[InstanceEdit:9948435] May, Bruce, 2025-05-20
compartment[Compartment:70101] cytosol
created[InstanceEdit:9948451] May, Bruce, 2025-05-21
edited[InstanceEdit:9948435] May, Bruce, 2025-05-20
input[GenomeEncodedEntity:379700] Ala-tRNA(Ala) [cytosol] [Homo sapiens]
[Complex:9948357] NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide [cytosol] [Homo sapiens]
internalReviewed[InstanceEdit:9960460] Matthews, Lisa, 2025-07-13
isChimericFALSE
literatureReference[LiteratureReference:9949722] Failure to Degrade CAT-Tailed Proteins Disrupts Neuronal Morphogenesis and Cell Survival
[LiteratureReference:9949737] Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing
modified[InstanceEdit:9949689] May, Bruce, 2025-05-24
[InstanceEdit:9949756] May, Bruce, 2025-05-26
[InstanceEdit:9953251] May, Bruce, 2025-05-30
[InstanceEdit:9954763] May, Bruce, 2025-06-08
[InstanceEdit:9955884] May, Bruce, 2025-06-12
[InstanceEdit:9960462] May, Bruce, 2025-07-13
[InstanceEdit:9962797] May, Bruce, 2025-08-09
[InstanceEdit:9971549] May, Bruce, 2025-11-07
nameNEMF polymerizes alanine residues onto the C-terminus of the nascent peptide ("CAT tailing")
output[GenomeEncodedEntity:141679] tRNA [cytosol] [Homo sapiens]
[Complex:9948304] NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala [cytosol] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
releaseDate2025-09-18
requiredInputComponent[EntityWithAccessionedSequence:3006310] Hyp-K50-EIF5A [cytosol] [Homo sapiens]
reviewed[InstanceEdit:9962796] Bennett, Eric J, 2025-08-09
[InstanceEdit:9962794] Ford, Pierce W, 2025-08-09
[InstanceEdit:9971505] Jafarnejad, Seyed Mehdi, 2025-11-07
[InstanceEdit:9971510] McGirr, Tom, 2025-11-07
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9948466] R-HSA-9948458.2
structureModified[InstanceEdit:9954763] May, Bruce, 2025-06-08
summation[Summation:9949678] NEMF transfers alanine residues from aminoacyl tRNAs to the ...
(hasEvent)[Pathway:9954709] Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9954723] NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 binds alanine-tailed nascent peptide [Homo sapiens]
[BlackBoxEvent:9954727] RCHY1 binds alanine-tailed nascent peptide and Ub:UBE2D2 [Homo sapiens]
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No pathways have been reviewed or authored by NEMF polymerizes alanine residues onto the C-terminus of the nascent peptide ("CAT tailing") (9948458)
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