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Details on Person ANKZF1 cleaves the C-terminal 3 nucleotides, CCA, of the tRN...

Class:IdSummation:9948441
_displayNameANKZF1 cleaves the C-terminal 3 nucleotides, CCA, of the tRN...
_timestamp2025-11-07 01:18:35
created[InstanceEdit:9948451] May, Bruce, 2025-05-21
literatureReference[LiteratureReference:9948460] The structural and functional basis of the p97/valosin-containing protein (VCP)-interacting motif (VIM): mutually exclusive binding of cofactors to the N-terminal domain of p97
[LiteratureReference:9971528] Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis
modified[InstanceEdit:9949904] May, Bruce, 2025-05-26
[InstanceEdit:9950592] May, Bruce, 2025-05-27
[InstanceEdit:9953251] May, Bruce, 2025-05-30
[InstanceEdit:9956788] May, Bruce, 2025-06-13
[InstanceEdit:9971549] May, Bruce, 2025-11-07
textANKZF1 cleaves the C-terminal 3 nucleotides, CCA, of the tRNA in the peptidyl-tRNA bound to the 60S ribosomal subunit, yielding a free tRNA and the nascent peptide covalently bound to the CCA sequence (Verma et al. 2018, Yip et al. 2019, and inferred from the yeast homolog, VMS1, in Verma et al. 2018, Yip et al. 2019). In yeast, Arb1 (mammalian ABCF2) occupies the E-site of the collided ribosome, extending a domain towards the peptidyl-tRNA that may help position it for release by Vms1/ANKZF1 (Su et al. 2019). ANKZF1 interacts strongly with VCP (Hänzelmann and Schindelin 2011).
(summation)[Reaction:9948427] ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide [Homo sapiens]
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