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Details on Person ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide

Class:Id	Reaction:9948427
_displayName	ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide
_doRelease	TRUE
_timestamp	2025-11-07 01:18:58
authored	[InstanceEdit:9948405] May, Bruce, 2025-05-20
catalystActivity	[CatalystActivity:9948420] RNA endonuclease activity of ANKZF1 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9948423] May, Bruce, 2025-05-20
edited	[InstanceEdit:9948405] May, Bruce, 2025-05-20
input	[Complex:9948416] VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9960460] Matthews, Lisa, 2025-07-13
isChimeric	FALSE
literatureReference	[LiteratureReference:9948454] Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes [LiteratureReference:9949698] Release of Ubiquitinated and Non-ubiquitinated Nascent Chains from Stalled Mammalian Ribosomal Complexes by ANKZF1 and Ptrh1 [LiteratureReference:9949901] Mechanism for recycling tRNAs on stalled ribosomes
modified	[InstanceEdit:9948467] May, Bruce, 2025-05-21 [InstanceEdit:9949756] May, Bruce, 2025-05-26 [InstanceEdit:9949904] May, Bruce, 2025-05-26 [InstanceEdit:9950603] May, Bruce, 2025-05-28 [InstanceEdit:9954763] May, Bruce, 2025-06-08 [InstanceEdit:9955884] May, Bruce, 2025-06-12 [InstanceEdit:9960462] May, Bruce, 2025-07-13 [InstanceEdit:9962797] May, Bruce, 2025-08-09 [InstanceEdit:9971549] May, Bruce, 2025-11-07
name	ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide
output	[GenomeEncodedEntity:141679] tRNA [cytosol] [Homo sapiens] [Complex:9948426] VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:K48polyUb-nascent peptide-Ala [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9948415] VCP hexamer and NPLOC4:UFD1 bind K48polyubiquitin of LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide [Homo sapiens] [Reaction:9948362] LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-09-18
reviewed	[InstanceEdit:9962796] Bennett, Eric J, 2025-08-09 [InstanceEdit:9962794] Ford, Pierce W, 2025-08-09 [InstanceEdit:9971505] Jafarnejad, Seyed Mehdi, 2025-11-07 [InstanceEdit:9971510] McGirr, Tom, 2025-11-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9948433] R-HSA-9948427.2
summation	[Summation:9948441] ANKZF1 cleaves the C-terminal 3 nucleotides, CCA, of the tRN...
(hasEvent)	[Pathway:9954709] Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide [Homo sapiens]
(precedingEvent)	[Reaction:9949632] VCP hexamer extracts K48 polyubiquitinated alanine-tailed nascent peptide from VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:K48polyUb-nascent peptide [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9971862] Update Tracker - [Reaction:9948427] ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide - v95:[modifyText]
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No pathways have been reviewed or authored by ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide (9948427)