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Details on Person LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide

Class:Id	Reaction:9948362
_displayName	LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide
_doRelease	TRUE
_timestamp	2025-11-07 01:20:44
authored	[InstanceEdit:9948347] May, Bruce, 2025-05-19
catalystActivity	[CatalystActivity:9960455] ubiquitin protein ligase activity of LTN1:TCF25:NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9948359] May, Bruce, 2025-05-20
edited	[InstanceEdit:9948347] May, Bruce, 2025-05-19
input	[Complex:8939319] Ub:UBE2D1 [cytosol] [Homo sapiens] [Complex:8939319] Ub:UBE2D1 [cytosol] [Homo sapiens] [Complex:8939319] Ub:UBE2D1 [cytosol] [Homo sapiens] [Complex:9948455] LTN1:TCF25:NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9960460] Matthews, Lisa, 2025-07-13
isChimeric	FALSE
literatureReference	[LiteratureReference:9948379] The ribosome-associated quality control factor TCF25 imposes K48 specificity on Listerin-mediated ubiquitination of nascent chains by binding and specifically orienting the acceptor ubiquitin [LiteratureReference:9949698] Release of Ubiquitinated and Non-ubiquitinated Nascent Chains from Stalled Mammalian Ribosomal Complexes by ANKZF1 and Ptrh1 [LiteratureReference:9953247] In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing [LiteratureReference:9949702] Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociation [LiteratureReference:9949752] Reconstitution of a minimal ribosome-associated ubiquitination pathway with purified factors
modified	[InstanceEdit:9948405] May, Bruce, 2025-05-20 [InstanceEdit:9948467] May, Bruce, 2025-05-21 [InstanceEdit:9949904] May, Bruce, 2025-05-26 [InstanceEdit:9950603] May, Bruce, 2025-05-28 [InstanceEdit:9953251] May, Bruce, 2025-05-30 [InstanceEdit:9955739] May, Bruce, 2025-06-11 [InstanceEdit:9955884] May, Bruce, 2025-06-12 [InstanceEdit:9960458] May, Bruce, 2025-07-12 [InstanceEdit:9960462] May, Bruce, 2025-07-13 [InstanceEdit:9962797] May, Bruce, 2025-08-09 [InstanceEdit:9971549] May, Bruce, 2025-11-07
name	LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide
output	[EntityWithAccessionedSequence:174236] UBE2D1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:174236] UBE2D1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:174236] UBE2D1 [cytosol] [Homo sapiens] [Complex:9948361] LTN1:TCF25:NEMF:60S ribosomal subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9948318] LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala [Homo sapiens] [Reaction:9948300] RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-09-18
reviewed	[InstanceEdit:9962796] Bennett, Eric J, 2025-08-09 [InstanceEdit:9962794] Ford, Pierce W, 2025-08-09 [InstanceEdit:9971505] Jafarnejad, Seyed Mehdi, 2025-11-07 [InstanceEdit:9971510] McGirr, Tom, 2025-11-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9948364] R-HSA-9948362.2
structureModified	[InstanceEdit:9948467] May, Bruce, 2025-05-21 [InstanceEdit:9960458] May, Bruce, 2025-07-12
summation	[Summation:9948386] LTN1 ubiquitinates exposed lysine residues on the nascent pe...
(hasEvent)	[Pathway:9954709] Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide [Homo sapiens]
(precedingEvent)	[Reaction:9948415] VCP hexamer and NPLOC4:UFD1 bind K48polyubiquitin of LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide [Homo sapiens]
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No pathways have been reviewed or authored by LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide (9948362)