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Details on Person RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide

Class:Id	Reaction:9948300
_displayName	RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide
_doRelease	TRUE
_timestamp	2025-11-07 01:24:55
authored	[InstanceEdit:9948322] May, Bruce, 2025-05-19
catalystActivity	[CatalystActivity:9948388] ATP hydrolysis activity of RQT complex:K63polyUb-80S Ribosome:no-go mRNA:peptidyl tRNA with nascent peptide [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9948292] May, Bruce, 2025-05-19
edited	[InstanceEdit:9948322] May, Bruce, 2025-05-19
input	[Complex:9948295] RQT complex:K63polyUb-80S Ribosome:no-go mRNA:peptidyl tRNA with nascent peptide [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
internalReviewed	[InstanceEdit:9960460] Matthews, Lisa, 2025-07-13
isChimeric	FALSE
literatureReference	[LiteratureReference:9948394] Identification of a novel trigger complex that facilitates ribosome-associated quality control in mammalian cells [LiteratureReference:9948308] Ribosomal collision is not a prerequisite for ZNF598-mediated ribosome ubiquitination and disassembly of ribosomal complexes by ASCC [LiteratureReference:9948384] A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation [LiteratureReference:9948419] The ASC-1 Complex Disassembles Collided Ribosomes
modified	[InstanceEdit:9948405] May, Bruce, 2025-05-20 [InstanceEdit:9948435] May, Bruce, 2025-05-20 [InstanceEdit:9949689] May, Bruce, 2025-05-24 [InstanceEdit:9954763] May, Bruce, 2025-06-08 [InstanceEdit:9955884] May, Bruce, 2025-06-12 [InstanceEdit:9960462] May, Bruce, 2025-07-13 [InstanceEdit:9962797] May, Bruce, 2025-08-09 [InstanceEdit:9971549] May, Bruce, 2025-11-07
name	RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide
output	[Complex:9948297] RQT complex [cytosol] [Homo sapiens] [Complex:9948305] K63polyUb-40S ribosomal subunit [cytosol] [Homo sapiens] [Complex:9948294] 60S ribosomal subunit:peptidyl-tRNA with nascent peptide [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:70106] H+ [cytosol] [GenomeEncodedEntity:9954739] no-go mRNA [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9948291] RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide [Homo sapiens] [Reaction:9948301] ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-09-18
reviewed	[InstanceEdit:9962796] Bennett, Eric J, 2025-08-09 [InstanceEdit:9962794] Ford, Pierce W, 2025-08-09 [InstanceEdit:9971505] Jafarnejad, Seyed Mehdi, 2025-11-07 [InstanceEdit:9971510] McGirr, Tom, 2025-11-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9948331] R-HSA-9948300.2
structureModified	[InstanceEdit:9948405] May, Bruce, 2025-05-20 [InstanceEdit:9949689] May, Bruce, 2025-05-24 [InstanceEdit:9954763] May, Bruce, 2025-06-08
summation	[Summation:9948380] The ribosome quality control trigger (RQT) complex (ASCC2:TR...
(hasEvent)	[Pathway:9954716] ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA [Homo sapiens]
(precedingEvent)	[Reaction:9948318] LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala [Homo sapiens] [Reaction:9948360] NEMF binds 60S ribosomal subunit:peptidyl-tRNA with nascent peptide [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9971893] Update Tracker - [Reaction:9948300] RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide - v95:[modifyText]
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No pathways have been reviewed or authored by RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide (9948300)