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Details on Person CASP5 cleaves GSDMD

Class:IdBlackBoxEvent:9947997
_displayNameCASP5 cleaves GSDMD
_doReleaseTRUE
_timestamp2025-08-18 13:53:34
authored[InstanceEdit:9947804] Shamovsky, Veronica, 2025-05-14
catalystActivity[CatalystActivity:9947985] cysteine-type endopeptidase activity of activated CASP5 [cytosol]
catalystActivityReference[CatalystActivityReference:9948014] cysteine-type endopeptidase activity of CASP5 dimer [cytosol] Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
compartment[Compartment:70101] cytosol
created[InstanceEdit:9947994] Shamovsky, Veronica, 2025-05-14
edited[InstanceEdit:9963520] Shamovsky, Veronica, 2025-08-14
input[EntityWithAccessionedSequence:6801577] GSDMD [cytosol] [Homo sapiens]
internalReviewed[InstanceEdit:9960500] Matthews, Lisa, 2025-07-09
isChimericFALSE
literatureReference[LiteratureReference:9647669] Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
[LiteratureReference:9647649] Inflammatory Caspases: Activation and Cleavage of Gasdermin-D In Vitro and During Pyroptosis
[LiteratureReference:9647624] Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor
[LiteratureReference:9686131] Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes
[LiteratureReference:9710021] Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis
modified[InstanceEdit:9948166] Shamovsky, Veronica, 2025-05-16
[InstanceEdit:9960494] Shamovsky, Veronica, 2025-07-14
[InstanceEdit:9963547] Shamovsky, Veronica, 2025-08-14
[InstanceEdit:9963953] Shamovsky, Veronica, 2025-08-18
nameCASP5 cleaves GSDMD
output[EntityWithAccessionedSequence:9647641] GSDMD(1-275) [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:9647672] GSDMD(276-484) [cytosol] [Homo sapiens]
precedingEvent
regulatedBy[NegativeRegulation:9686115] Negative regulation by 'Caspase-3 [cytosol]'
regulationReference[RegulationReference:9686101] Negative regulation by 'Caspase-3 [cytosol]' Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages
releaseDate2025-09-18
reviewed[InstanceEdit:9963135] Shi, Xuyan, 2025-08-12
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9948022] R-HSA-9947997.1
summation[Summation:9948167] Caspase-5 (CASP5), along with caspase-4 (CASP4), is activate...
(hasEvent)[Pathway:5620971] Pyroptosis [Homo sapiens]
[Pathway:9960525] CASP5-mediated substrate cleavage [Homo sapiens]
(precedingEvent)[Reaction:9647631] GSDMD (1-275) binds PIPs [Homo sapiens]
[Reaction:9647643] GSDMD (1-275) binds bacterial cardiolipin [Homo sapiens]
[Reaction:9710353] GSDMD (1-275) binds cardiolipin [Homo sapiens]
(replacementInstances)[_Deleted:9964018] Deletion of instance: 9710101
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No pathways have been reviewed or authored by CASP5 cleaves GSDMD (9947997)
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