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Details on Person CASP5 cleaves IL18 at D36

Class:IdBlackBoxEvent:9947978
_displayNameCASP5 cleaves IL18 at D36
_doReleaseTRUE
_timestamp2025-08-18 13:53:37
authored[InstanceEdit:9947804] Shamovsky, Veronica, 2025-05-14
catalystActivity[CatalystActivity:9947985] cysteine-type endopeptidase activity of activated CASP5 [cytosol]
catalystActivityReference[CatalystActivityReference:9960496] cysteine-type endopeptidase activity of activated CASP5 [cytosol] Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome
compartment[Compartment:70101] cytosol
created[InstanceEdit:9947994] Shamovsky, Veronica, 2025-05-14
edited[InstanceEdit:9963520] Shamovsky, Veronica, 2025-08-14
input[EntityWithAccessionedSequence:449033] IL18(1-193) [cytosol] [Homo sapiens]
internalReviewed[InstanceEdit:9960500] Matthews, Lisa, 2025-07-09
isChimericFALSE
literatureReference[LiteratureReference:9947979] Structural insights into cytokine cleavage by inflammatory caspase-4
[LiteratureReference:9947810] Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome
[LiteratureReference:9958631] The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases
modified[InstanceEdit:9953148] Shamovsky, Veronica, 2025-05-28
[InstanceEdit:9958641] Shamovsky, Veronica, 2025-06-24
[InstanceEdit:9958785] Shamovsky, Veronica, 2025-06-25
[InstanceEdit:9960494] Shamovsky, Veronica, 2025-07-14
[InstanceEdit:9960533] Shamovsky, Veronica, 2025-07-14
[InstanceEdit:9963547] Shamovsky, Veronica, 2025-08-14
[InstanceEdit:9963953] Shamovsky, Veronica, 2025-08-18
nameCASP5 cleaves IL18 at D36
output[EntityWithAccessionedSequence:449062] IL18(1-36) [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:449023] IL18(37-193) [cytosol] [Homo sapiens]
precedingEvent
releaseDate2025-09-18
reviewed[InstanceEdit:9963135] Shi, Xuyan, 2025-08-12
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9948026] R-HSA-9947978.1
structureModified[InstanceEdit:9958785] Shamovsky, Veronica, 2025-06-25
[InstanceEdit:9960494] Shamovsky, Veronica, 2025-07-14
summation[Summation:9960497] Similar to CASP4, CASP5 efficiently cleaves pro-interleukin-...
(hasEvent)[Pathway:9960525] CASP5-mediated substrate cleavage [Homo sapiens]
(precedingEvent)[BlackBoxEvent:449058] Interleukin-1 family are secreted [Homo sapiens]
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No pathways have been reviewed or authored by CASP5 cleaves IL18 at D36 (9947978)