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Details on Person CASP4 forms dimers on the bacterial surface

Class:Id	Polymerisation:9947940
_displayName	CASP4 forms dimers on the bacterial surface
_doRelease	TRUE
_timestamp	2025-08-18 13:53:21
authored	[InstanceEdit:9947804] Shamovsky, Veronica, 2025-05-14
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9947847] Shamovsky, Veronica, 2025-05-14
edited	[InstanceEdit:9963520] Shamovsky, Veronica, 2025-08-14
input	[Complex:9947893] CASP4:LPS:(GBP1:GBP2:GBP3:GBP4:GDP) oligomer [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:622418] CASP4(?-377) [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9960500] Matthews, Lisa, 2025-07-09
isChimeric	FALSE
literatureReference	[LiteratureReference:9652838] Inflammatory caspases are innate immune receptors for intracellular LPS
modified	[InstanceEdit:9953128] Shamovsky, Veronica, 2025-05-28 [InstanceEdit:9960494] Shamovsky, Veronica, 2025-07-14 [InstanceEdit:9963538] Shamovsky, Veronica, 2025-08-14 [InstanceEdit:9963953] Shamovsky, Veronica, 2025-08-18
name	CASP4 forms dimers on the bacterial surface
output	[Complex:9947938] 2xCASP4:LPS:(GBP1:GBP2:GBP3:GBP4:GDP) oligomer [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9947934] CASP4 binds exposed LPS on the bacterial surface [Homo sapiens] [Polymerisation:9947876] GBP1:GBP2:GBP3:GBP4 forms higher-order structures [Homo sapiens]
regulatedBy	[NegativeRegulation:9953129] Negative regulation by 'CASP4:SERPINB1 [cytosol]'
regulationReference	[RegulationReference:9953127] Negative regulation by 'CASP4:SERPINB1 [cytosol]' SERPINB1-mediated checkpoint of inflammatory caspase activation
releaseDate	2025-09-18
reviewed	[InstanceEdit:9963135] Shi, Xuyan, 2025-08-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9947950] R-HSA-9947940.1
structureModified	[InstanceEdit:9953128] Shamovsky, Veronica, 2025-05-28 [InstanceEdit:9960494] Shamovsky, Veronica, 2025-07-14
summation	[Summation:9947864] Upon sensing cytoplasmic LPS, caspase-4 (CASP4) forms oligom...
(hasEvent)	[Pathway:9948001] CASP4 inflammasome assembly [Homo sapiens]
(precedingEvent)	[Reaction:9947908] CASP4 autocatalysis on the bacterial surface [Homo sapiens]
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No pathways have been reviewed or authored by CASP4 forms dimers on the bacterial surface (9947940)