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Details on Person GBP1 hydrolyzes GDP

Class:IdReaction:9947887
_displayNameGBP1 hydrolyzes GDP
_doReleaseTRUE
_timestamp2025-11-06 22:40:36
authored[InstanceEdit:9963520] Shamovsky, Veronica, 2025-08-14
catalystActivity[CatalystActivity:9947947] GDP phosphatase activity of GBP1 oligomer:GDP:LPS [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9947847] Shamovsky, Veronica, 2025-05-14
edited[InstanceEdit:9970963] Shamovsky, Veronica, 2025-11-03
entityOnOtherCell[SimpleEntity:6803081] LPS [peptidoglycan-based cell wall]
input[Complex:9947863] GBP1 oligomer:GDP:LPS [cytosol] [Homo sapiens]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:29356] H2O [cytosol]
internalReviewed[InstanceEdit:9968331] Matthews, Lisa, 2025-10-13
isChimericFALSE
literatureReference[LiteratureReference:9947931] How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP
[LiteratureReference:9953141] The interferon-induced 67-kDa guanylate-binding protein (hGBP1) is a GTPase that converts GTP to GMP
[LiteratureReference:9947890] Structural insights into the activation mechanism of antimicrobial GBP1
[LiteratureReference:9947914] Catalytic activity of human guanylate-binding protein 1 coupled to the release of structural restraints imposed by the C-terminal domain
modified[InstanceEdit:9953148] Shamovsky, Veronica, 2025-05-28
[InstanceEdit:9968559] Shamovsky, Veronica, 2025-10-16
[InstanceEdit:9970623] Shamovsky, Veronica, 2025-10-31
[InstanceEdit:9970965] Shamovsky, Veronica, 2025-11-03
[InstanceEdit:9971501] Shamovsky, Veronica, 2025-11-06
nameGBP1 hydrolyzes GDP
output[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:29372] Pi [cytosol]
[SimpleEntity:29372] Pi [cytosol]
[Complex:9947870] GBP1 oligomer:GMP:LPS [cytosol] [Homo sapiens]
precedingEvent
releaseDate2025-12-08
reviewed[InstanceEdit:9970618] Daumke, Oliver, 2025-10-31
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9947971] R-HSA-9947887.1
structureModified[InstanceEdit:9953148] Shamovsky, Veronica, 2025-05-28
summation[Summation:9953142] Guanylate-binding protein 1 (GBP1) catalyzes a two-step GTP ...
(hasEvent)[Pathway:9953170] GBP-mediated host defense [Homo sapiens]
(precedingEvent)[Reaction:9953173] GMP dissociates from the GBP1 oligomer [Homo sapiens]
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