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Details on Person Guanylate-binding protein 1 (GBP1) localizes to the lipopoly...

Class:IdSummation:9947871
_displayNameGuanylate-binding protein 1 (GBP1) localizes to the lipopoly...
_timestamp2025-06-24 06:09:50
created[InstanceEdit:9947847] Shamovsky, Veronica, 2025-05-14
literatureReference[LiteratureReference:9947948] Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria
[LiteratureReference:9947834] Nucleotide-dependent farnesyl switch orchestrates polymerization and membrane binding of human guanylate-binding protein 1
[LiteratureReference:9947892] Structural basis of antimicrobial membrane coat assembly by human GBP1
[LiteratureReference:9947890] Structural insights into the activation mechanism of antimicrobial GBP1
[LiteratureReference:9947832] Structural requirements for membrane binding of human guanylate-binding protein 1
[LiteratureReference:9947914] Catalytic activity of human guanylate-binding protein 1 coupled to the release of structural restraints imposed by the C-terminal domain
[LiteratureReference:9947909] Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions
modified[InstanceEdit:9948173] Shamovsky, Veronica, 2025-05-16
[InstanceEdit:9958674] Shamovsky, Veronica, 2025-06-24
textGuanylate-binding protein 1 (GBP1) localizes to the lipopolysaccharide (LPS)-rich outer membranes of cytosolic Gram-negative bacteria in GTP-dependent manner (Kutsch M et al., 2020; Santos JC et al., 2020). It binds bacterial LPS with high affinity through electrostatic interactions. Membrane association of GBP1 depends largely on the accessibility of its farnesyl tail (Shydlovskyi S et al., 2017). In its inactive state without nucleotides, GBP1 is a monomer with the farnesyl group sequestered within a hydrophobic pocket, preventing membrane interaction. GTP binding to GBP1 triggers structural shifts enabling exposure of the farnesyl moiety of GBP1 for membrane interaction, GTPase activation, and oligomerization of GBP1 on bacterial membranes (Shydlovskyi S et al., 2017; Sistemich L et al., 2021; Ince S et al., 2021; Weismehl M et al., 2024; Kuhm T et al., 2025).
(summation)[Reaction:9947932] GBP1:GTP binds LPS on the bacterial surface [Homo sapiens]
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