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Details on Person CASP4 autocatalysis on LPS micelles

Class:IdBlackBoxEvent:9947861
_displayNameCASP4 autocatalysis on LPS micelles
_doReleaseTRUE
_timestamp2025-08-18 13:52:57
authored[InstanceEdit:9947804] Shamovsky, Veronica, 2025-05-14
catalystActivity[CatalystActivity:9947838] cysteine-type endopeptidase activity of 2xCASP4:LPS micelles [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9947847] Shamovsky, Veronica, 2025-05-14
edited[InstanceEdit:9963520] Shamovsky, Veronica, 2025-08-14
input[Complex:9686270] 2xCASP4:LPS micelles [cytosol] [Homo sapiens]
internalReviewed[InstanceEdit:9960500] Matthews, Lisa, 2025-07-09
isChimericFALSE
literatureReference[LiteratureReference:9947803] Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme
[LiteratureReference:9647649] Inflammatory Caspases: Activation and Cleavage of Gasdermin-D In Vitro and During Pyroptosis
[LiteratureReference:9710021] Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis
modified[InstanceEdit:9953128] Shamovsky, Veronica, 2025-05-28
[InstanceEdit:9960494] Shamovsky, Veronica, 2025-07-14
[InstanceEdit:9963531] Shamovsky, Veronica, 2025-08-14
[InstanceEdit:9963953] Shamovsky, Veronica, 2025-08-18
nameCASP4 autocatalysis on LPS micelles
output[Complex:9710097] activated CASP4 [cytosol] [Homo sapiens]
[SimpleEntity:9686105] LPS micelles [bacterial outer membrane vesicle]
[EntityWithAccessionedSequence:9947833] CASP4(271-289) [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:9947833] CASP4(271-289) [cytosol] [Homo sapiens]
precedingEvent
regulatedBy[NegativeRegulation:9958625] Negative regulation by 'CALM:OspC3:CASP4:LPS [cytosol]'
regulationReference[RegulationReference:9958660] Negative regulation by 'CALM:OspC3:CASP4:LPS [cytosol]' Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis
releaseDate2025-09-18
reviewed[InstanceEdit:9963135] Shi, Xuyan, 2025-08-12
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9947949] R-HSA-9947861.1
structureModified[InstanceEdit:9960494] Shamovsky, Veronica, 2025-07-14
summation[Summation:9947867] Once pro-caspase-4 (CASP4) monomers are brought into close p...
(hasEvent)[Pathway:9948001] CASP4 inflammasome assembly [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9947987] CASP4 cleaves IL18 at D36 [Homo sapiens]
[BlackBoxEvent:9948146] CASP4 cleaves GSDMD [Homo sapiens]
[BlackBoxEvent:9958657] CASP4 cleaves IL1B at D27 [Homo sapiens]
[BlackBoxEvent:9960526] CASP4 cleaves IL1B at D116 [Homo sapiens]
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No pathways have been reviewed or authored by CASP4 autocatalysis on LPS micelles (9947861)
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