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Details on Person Dengue virion binds CLEC5A

Class:IdReaction:9947771
_displayNameDengue virion binds CLEC5A
_doReleaseTRUE
_timestamp2025-12-03 15:38:15
authored[InstanceEdit:9918832] Stephan, Ralf, 2024-08-18
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9947762] Stephan, Ralf, 2025-05-14
disease[Disease:3244610] dengue disease
edited[InstanceEdit:9970471] Stephan, Ralf, 2025-10-30
input[Complex:9922290] DENV-2 virion [extracellular region] [Dengue virus type 2]
[Complex:9947796] CLEC5A dimer [plasma membrane] [Homo sapiens]
internalReviewed[InstanceEdit:9970111] Orlic-Milacic, Marija, 2025-10-27
isChimericFALSE
literatureReference[LiteratureReference:2426398] CLEC5A is critical for dengue-virus-induced lethal disease
[LiteratureReference:9947784] Structural flexibility of the macrophage dengue virus receptor CLEC5A: implications for ligand binding and signaling
[LiteratureReference:9947778] CLEC5A: A Promiscuous Pattern Recognition Receptor to Microbes and Beyond
[LiteratureReference:9947791] Association of rs1285933 single nucleotide polymorphism in CLEC5A gene with dengue severity and its functional effects
[LiteratureReference:9948205] CLEC2 and CLEC5A: Pathogenic Host Factors in Acute Viral Infections
[LiteratureReference:9945988] Dengue Virus Infection Is through a Cooperative Interaction between a Mannose Receptor and CLEC5A on Macrophage as a Multivalent Hetero-Complex
modified[InstanceEdit:9947795] Stephan, Ralf, 2025-05-14
[InstanceEdit:9948204] Stephan, Ralf, 2025-05-17
[InstanceEdit:9948226] Stephan, Ralf, 2025-05-18
[InstanceEdit:9963605] Stephan, Ralf, 2025-08-15
[InstanceEdit:9964204] Stephan, Ralf, 2025-08-20
[InstanceEdit:9966337] Stephan, Ralf, 2025-09-19
[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
[InstanceEdit:9971555] Stephan, Ralf, 2025-11-07
[InstanceEdit:9975896] Stephan, Ralf, 2025-12-03
nameDengue virion binds CLEC5A
output[Complex:9947764] DENV-2 virion:CLEC5A [plasma membrane] [Homo sapiens]
previousReviewStatus[ReviewStatus:9821383] three stars
relatedSpecies[Species:3244621] Dengue virus type 2
releaseDate2025-12-08
reviewed[InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29
[InstanceEdit:9970204] Mansur, Daniel Santos, 2025-10-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9947794] R-HSA-9947771.2
structureModified[InstanceEdit:9947795] Stephan, Ralf, 2025-05-14
summation[Summation:9947769] On monocytes and macrophages, Dengue virions (serotypes 1-4)...
(hasEvent)[Pathway:9920588] Dengue virus activates/modulates innate and adaptive immune responses [Homo sapiens]
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No pathways have been reviewed or authored by Dengue virion binds CLEC5A (9947771)
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